Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice.

	Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice.
	Fan, Xiujun; Zhang, Baozhen; Tan, Lunbo; Yu, Yan; Wang, Baobei; Chen, Zhilong; Han, Jinyu; Li, Mengxia; Chen, Jie; Xiao, Tianxia
刊名	THERANOSTICS
	2018
文献子类	期刊论文
英文摘要	Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum-infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) on the surfaces of trophoblasts. Based on this principle, we have developed a method for targeted delivery of payloads to the placenta using a synthetic placental CSA-binding peptide (plCSA-BP) derived from VAR2CSA, a CSA-binding protein expressed on IEs.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14686]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Fan, Xiujun,Zhang, Baozhen,Tan, Lunbo,et al. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice.[J]. THERANOSTICS,2018.
APA	Fan, Xiujun.,Zhang, Baozhen.,Tan, Lunbo.,Yu, Yan.,Wang, Baobei.,...&Zhang, Jian.(2018).Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice..THERANOSTICS.
MLA	Fan, Xiujun,et al."Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice.".THERANOSTICS (2018).