Cancer cells fluorescence lifetime imaging based on aptamer functionalized core/shell ZnSe:Mn/ZnS quantum dots

	Cancer cells fluorescence lifetime imaging based on aptamer functionalized core/shell ZnSe:Mn/ZnS quantum dots
	Dapeng Ni; Chi Chen; Haodong Cui; Ping Gong; Lintao Cai
刊名	Nanomedicine: Nanotechnology, Biology and Medicine
	2018
文献子类	会议论文
英文摘要	Compared with organic dyes, quantum dots (QDs) can be regarded as an excellent candidate for fluorescence lifetime imaging, due to its relatively long fluorescence lifetime, narrow and symmetric emission peak, high photostability, and high photoluminescence quantum yield.It had been well established that the fluorescence of Mn-doped ZnSe nanocrystals at a wavelength around 580 nm was from the transition 4T1to 6A1 of the Mn2+ions in the crystal field of the ZnSe nanocrystals,which always possessed longer lifetime.In this study, we developed a novel strategy to synthesize aptamer (as1411) functionalized water soluble core/shell ZnSe:Mn/ZnS QDs with long fluorescence lifetime(0.2 ms). The Mn-doped ZnSe core was prepared by a nucleation doping approach, and a ZnS shell was grown on ZnSe: Mn2+core throughaddingof Zn2+, 3-mercaptopropionic acid (MPA) and thiourea under appropriate pH conditions. Moreover, as1411 functionalized doped QDs can uniquely identify and track cancer cells in different cells mixture. Furthermore, as-prepared QDs could be used as targeted probes for cancer cells fluorescence lifetime imaging.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14627]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Dapeng Ni,Chi Chen,Haodong Cui,et al. Cancer cells fluorescence lifetime imaging based on aptamer functionalized core/shell ZnSe:Mn/ZnS quantum dots[J]. Nanomedicine: Nanotechnology, Biology and Medicine,2018.
APA	Dapeng Ni,Chi Chen,Haodong Cui,Ping Gong,&Lintao Cai.(2018).Cancer cells fluorescence lifetime imaging based on aptamer functionalized core/shell ZnSe:Mn/ZnS quantum dots.Nanomedicine: Nanotechnology, Biology and Medicine.
MLA	Dapeng Ni,et al."Cancer cells fluorescence lifetime imaging based on aptamer functionalized core/shell ZnSe:Mn/ZnS quantum dots".Nanomedicine: Nanotechnology, Biology and Medicine (2018).