Multiregional Radiomics Profiling from Multiparametric MRI: Identifying an Imaging Predictor of IDH1 Mutation Status in Glioblastoma

	Multiregional Radiomics Profiling from Multiparametric MRI: Identifying an Imaging Predictor of IDH1 Mutation Status in Glioblastoma
	Chaofeng Liang; Zhi-Cheng Li; Hongmin Bai; Qiuchang Sun; Yuanshen Zhao; Yanchun Lv; Jian Zhou; Yinsheng Chen; Dong Liang; Hairong Zheng
刊名	Cancer Medicine
	2018
文献子类	期刊论文
英文摘要	Purpose: Isocitrate dehydrogenase 1 (IDH1) has been proven as a prognostic and predictive marker in Glioblastoma (GBM) patients. The purpose was to preoperatively predict IDH mutation status in GBM using multiregional radiomics features from multiparametric magnetic resonance imaging (MRI). Methods: In this retrospective multicenter study, 225 patients were included. 1614 multiregional features were extracted from enhancement area, non-enhancement area, necrosis, edema, tumor core, and whole tumor in multiparametric MRI. Three multiregional radiomics models were built from tumor core, whole tumor and all regions using an all-relevant feature selection and a random forest classification for predicting IDH1. Four single-region models and a model combining all-region features with clinical factors (age, sex, and Karnofsky performance status) were also built. All models were built from a training cohort (118 patients) and tested on an independent validation cohort (107 patients). Results: Among four single-region radiomics models, the edema model achieved the best accuracy of 96% and the best F1-score of 0.75 while the non-enhancement model achieved the best AUC of 0.88 in the validation cohort. The overall performance of the tumor-core model (accuracy 0.96, AUC 0.86 and F1-score 0.75) and the whole-tumor model (accuracy 0.96, AUC 0.88 and F1-score 0.75) was slightly better than the single-regional models. The 8-feature all-region radiomics model achieved an improved overall performance of an accuracy 96%, an AUC 0.90 and an F1-score 0.78. Among all models, the model combining all-region imaging features with age achieved the best performance of an accuracy 97%, an AUC 0.96 and an F1-score 0.84. Conclusions: The radiomics model built with multiregional features from multiparametric MRI has the potential to preoperatively detect the IDH1 mutation status in GBM patients. The multiregional model built with all-region features performed better than the single-region models, while combining age with all-region features achieved the best performance.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14447]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Chaofeng Liang,Zhi-Cheng Li,Hongmin Bai,et al. Multiregional Radiomics Profiling from Multiparametric MRI: Identifying an Imaging Predictor of IDH1 Mutation Status in Glioblastoma[J]. Cancer Medicine,2018.
APA	Chaofeng Liang.,Zhi-Cheng Li.,Hongmin Bai.,Qiuchang Sun.,Yuanshen Zhao.,...&Hairong Zheng.(2018).Multiregional Radiomics Profiling from Multiparametric MRI: Identifying an Imaging Predictor of IDH1 Mutation Status in Glioblastoma.Cancer Medicine.
MLA	Chaofeng Liang,et al."Multiregional Radiomics Profiling from Multiparametric MRI: Identifying an Imaging Predictor of IDH1 Mutation Status in Glioblastoma".Cancer Medicine (2018).