Atomic force microscopy methodology and AFMech Suite software for nanomechanics on heterogeneous soft materials

	Atomic force microscopy methodology and AFMech Suite software for nanomechanics on heterogeneous soft materials
	Florian J. Stadler; Guanlin Tang; Chandra S. Biswas; Jinlai Zha; Shiguo Chen; Massimiliano Galluzzi
刊名	NATURE COMMUNICATIONS
	2018
文献子类	期刊论文
英文摘要	Atomic force microscopy has proven to be a valuable technique to characterize the mechanical and morphological properties of heterogeneous soft materials such as biological specimens in liquid environment. Here we propose a 3-step method in order to investigate biological specimens where heterogeneity hinder a quantitative characterization: (1) precise AFM calibration, (2) nano-indentation in force volume mode, (3) array of finite element simulations built from AFM indentation events. We combine simulations to determine internal geometries, multi-layer material properties, and interfacial friction. In order to easily perform this analysis from raw AFM data to simulation comparison, we propose a standalone software, AFMech Suite comprising five interacting interfaces for simultaneous calibration, morphology, adhesion, mechanical, and simulation analysis. We test the methodology on soft hydrogels with hard spherical inclusions, as a soft-matter model system. Finally, we apply the method on E. coli bacteria supported on soft/hard hydrogels to prove usefulness in biological field.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14411]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Florian J. Stadler,Guanlin Tang,Chandra S. Biswas,et al. Atomic force microscopy methodology and AFMech Suite software for nanomechanics on heterogeneous soft materials[J]. NATURE COMMUNICATIONS,2018.
APA	Florian J. Stadler,Guanlin Tang,Chandra S. Biswas,Jinlai Zha,Shiguo Chen,&Massimiliano Galluzzi.(2018).Atomic force microscopy methodology and AFMech Suite software for nanomechanics on heterogeneous soft materials.NATURE COMMUNICATIONS.
MLA	Florian J. Stadler,et al."Atomic force microscopy methodology and AFMech Suite software for nanomechanics on heterogeneous soft materials".NATURE COMMUNICATIONS (2018).