Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications

	Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications
	Tsai, Chih-Hung; Liu, Hao-Li; Jan, Chen-Kai; Chang, Hsin-Yu; Huang, Sheng-Min; Li, Meng-Lin; Qiu, Weibao; Zheng, Hairong
刊名	IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
	2018
文献子类	期刊论文
英文摘要	Focused ultrasound phased array systems have attracted increased attention for brain therapy applications. However, such systems currently lack a direct and real-time method to intraoperatively monitor ultrasound pressure distribution for securing treatment. This study proposes a dual-mode ultrasoundphased array system design to support transmit/receive operations for concurrent ultrasound exposure and backscattered focal beam reconstruction through a spherically focused ultrasound array. A 256-channel ultrasound transmission system was used to transmit focused ultrasonic energy (full 256 channels), with an extended implementation of multiple-channel receiving function (up to 64 channels) using the same 256-channel ultrasound array. Acoherent backscatter-received beam formation algorithm was implemented to map the point spread function (PSF) and focal beam distribution under a free-field/transcranial environment setup, with the backscattering generated from a strong scatterer (a point reflector or a microbubble-perfused tube) or aweakly scattered tissue-mimicking graphite phantom. Our results showed that PSF and focal beam can be successfully reconstructed and visualized in free-field conditions and can also be transcranially reconstructed following skull-induced aberration correction. In vivo experiments were conducted to demonstrate its capability to preoperatively and semiquantitatively map a focal beam to guide blood-brain barrier opening. The proposed system may have potential for real-time guidance of ultrasound brain intervention, and may facilitate the design of a dual-mode ultrasound phased array for brain therapeutic applications.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14361]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Tsai, Chih-Hung,Liu, Hao-Li,Jan, Chen-Kai,et al. Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications[J]. IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL,2018.
APA	Tsai, Chih-Hung.,Liu, Hao-Li.,Jan, Chen-Kai.,Chang, Hsin-Yu.,Huang, Sheng-Min.,...&Zheng, Hairong.(2018).Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications.IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL.
MLA	Tsai, Chih-Hung,et al."Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications".IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL (2018).