Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery

	Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery
	Li, Yue; Yan, Fei; Zheng, Hairong; Yu, Jinsui; Chen, Zhiyi; Du, Meng
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2018
文献子类	期刊论文
英文摘要	To attain attractive ultrasound-responsive gene delivery, a new kind of echogenic chitosan nanodroplets (CND) was developed to explore the potential to deliver genes in a spatiotemporally controlled manner. Self-assembled amphiphilic chitosan micelles of nanoscale size were fabricated to encapsulate hydrophobic perfluoropentane into the inner cores. The resulting CND presented a positive surface charge. enabling the formation of nano-complexes with genetic cargo through electrostatic interactions. Agarose-gel electrophoresis further confirmed the ability of CND to bind DNA. CND was also observed to protect DNA from degradation by nucleases. A temperature-dependent droplet-to-bubble conversion was also demonstrated. More importantly, our study revealed that CND in combination with ultrasound could significantly enhance gene delivery. In conclusion, our study demonstrated a novel carrier with great potential for efficient ultrasound-mediated gene delivery to specific tissues in a spatiotemporally controlled manner.
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14337]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Li, Yue,Yan, Fei,Zheng, Hairong,et al. Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2018.
APA	Li, Yue,Yan, Fei,Zheng, Hairong,Yu, Jinsui,Chen, Zhiyi,&Du, Meng.(2018).Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY.
MLA	Li, Yue,et al."Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018).