Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment.

	Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment.
	Chen, Jingqin; Yan, Fei; Zheng, Hairong; Wu, Meiying; Chen, Wenting; Chen, Yu; Zhang, Haixian; Liu, Chengbo; Deng, Zhiting; Sheng, Zonghai
刊名	ADVANCED SCIENCE
	2018
文献子类	期刊论文
英文摘要	The blood brain barrier is the main obstacle to delivering diagnostic and therapeutic agents to the diseased sites of brain. It is still of great challenge for the combined use of focused ultrasound (FUS) and theranostic nanotechnology to achieve noninvasive and localized delivery of chemotherapeutic drugs into orthotopic brain tumor. In this work, a unique theranostic nanoplatform for highly efficient photoacoustic imaging-guided chemotherapy of brain tumorboth in vitro and in vivo, which is based on the utilization of hollow mesoporous organosilica nanoparticles (HMONs) to integrate ultrasmall Cu2-xSe particles on the surface and doxorubicin inside the hollow interior, is synthesized. The developed multifunctional theranostic nanosystems exhibit tumor-triggered programmed destruction due to the reducing microenvironment-responsive cleavage of disulfide bonds that are incorporated into the framework of HMONs and linked between HMONs and Cu2-xSe, resulting in tumor-specific biodegradation and on-demand drug-releasing behavior. Such tumormicroenvironment-responsive biodegradable and biocompatible theranostic nanosystems in combination with FUS provide a promising deliverynanoplatform with high performance for orthotopic brain tumor imaging and therapy.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14327]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Chen, Jingqin,Yan, Fei,Zheng, Hairong,et al. Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment.[J]. ADVANCED SCIENCE,2018.
APA	Chen, Jingqin.,Yan, Fei.,Zheng, Hairong.,Wu, Meiying.,Chen, Wenting.,...&Liu, Xin.(2018).Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment..ADVANCED SCIENCE.
MLA	Chen, Jingqin,et al."Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment.".ADVANCED SCIENCE (2018).