Dual extra-retinal origins of microglia in the model of retinal microglia repopulation.

	Dual extra-retinal origins of microglia in the model of retinal microglia repopulation.
	So, Kwok-Fai; Peng, Bo; Rao, Yanxia; Huang, Yubin; Xu, Zhen; Xiong, Shanshan; Qin, Guangrong; Sun, Fangfang; Yang, Jian; Yuan, Ti-Fei
刊名	CELL DISCOVERY
	2018
文献子类	期刊论文
英文摘要	Elucidating the origin of microglia is crucial for understanding their functions and homeostasis. Previous study has indicated that Nestin-positive progenitor cells differentiate into microglia and replenish the brain after depleting most brain microglia. Microglia have also shown the capacity to repopulate the retina after eliminating all retinal microglia. However, the origin(s) of repopulated retinal microglia is/are unknown. In this study, we aim to investigate the originsof repopulated microglia in the retina. Interestingly, we find that repopulated retinal microglia are not derived from Nestin-positive progenitor cells. Instead, they have two origins: the center-emerging microglia are derived from residual microglia in the optic nerve and the periphery-emerging microglia are derived from macrophages in the ciliary body/iris. Therefore, we have for the first time identified the extra-retinal origins of microglia in the adult mammalian retina by using a model of microglial repopulation, which may shed light on the target exploration of therapeutic interventions for retinaldegenerative disorders.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14274]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	So, Kwok-Fai,Peng, Bo,Rao, Yanxia,et al. Dual extra-retinal origins of microglia in the model of retinal microglia repopulation.[J]. CELL DISCOVERY,2018.
APA	So, Kwok-Fai.,Peng, Bo.,Rao, Yanxia.,Huang, Yubin.,Xu, Zhen.,...&Wu, Tianzhun.(2018).Dual extra-retinal origins of microglia in the model of retinal microglia repopulation..CELL DISCOVERY.
MLA	So, Kwok-Fai,et al."Dual extra-retinal origins of microglia in the model of retinal microglia repopulation.".CELL DISCOVERY (2018).