Highly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal Nanoprobes

	Highly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal Nanoprobes
	Zheng, Hairong; Sun, Mingjian; Lin, Xiangwei; Liu, Chengbo; Sheng, Zonghai; Gong, Xiaojing; Song, Liang; Zhang, Ruifang
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018
文献子类	期刊论文
英文摘要	The biomedical imaging of metastatic breast cancer, especially in lymphatic and lung metastasis, is highly significant in cancer staging as it helps assess disease prognosis and treatment. Using an albumin-indocyanine green dual-modal nanoprobe developed in our laboratory, in vivo fluorescence imaging and photoacoustic imaging of metastatic breast cancer tumors were performed separately. Fluorescence imaging at the near-infrared window features high imaging sensitivity but is generally limited by a low imaging depth. Thus, tumors can only be observed in situ whereas tumor cells in the lymph nodes and lung cannot be imaged in a precise manner. In contrast, photoacoustic imaging often helps overcome the limitations of imaging depth with high acoustic spatial resolution, which could provide complementary information for imaging cancer metastases. Ex vivo fluorescence and photoacoustic imaging were also performed to verify the tumor metastatic route. This study may not only provide insights into the design of dual-modal nanoprobes for breast cancer diagnosis but may also demonstrate the superiority of combined fluorescence imaging and photoacoustic imaging for guiding, monitoring, and evaluating lymphatic and lung metastatic stages of breast cancer with a high imaging specificity as well as sensitivity.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14219]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Zheng, Hairong,Sun, Mingjian,Lin, Xiangwei,et al. Highly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal Nanoprobes[J]. ACS APPLIED MATERIALS & INTERFACES,2018.
APA	Zheng, Hairong.,Sun, Mingjian.,Lin, Xiangwei.,Liu, Chengbo.,Sheng, Zonghai.,...&Zhang, Ruifang.(2018).Highly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal Nanoprobes.ACS APPLIED MATERIALS & INTERFACES.
MLA	Zheng, Hairong,et al."Highly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal Nanoprobes".ACS APPLIED MATERIALS & INTERFACES (2018).