Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site.

	Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site.
	Zheng, Hairong; Zhang, Peng; Sheng, Zonghai; Song, Liang; Liu, Chengbo; Chen, Jingqin; Zhu, Ying; Gong, Xiaojing; Zheng, Rongqin; Chen, Ningbo
刊名	NANO-MICRO LETTERS
	2018
文献子类	期刊论文
英文摘要	Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS2-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS2-ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS2-ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14212]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Zheng, Hairong,Zhang, Peng,Sheng, Zonghai,et al. Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site.[J]. NANO-MICRO LETTERS,2018.
APA	Zheng, Hairong.,Zhang, Peng.,Sheng, Zonghai.,Song, Liang.,Liu, Chengbo.,...&Yan, Huixiang.(2018).Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site..NANO-MICRO LETTERS.
MLA	Zheng, Hairong,et al."Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site.".NANO-MICRO LETTERS (2018).