A Laser-Activated Biocompatible Theranostic Nanoagent for Targeted Multimodal Imaging and Photothermal Therapy

doi:10.7150/thno.21283

	A Laser-Activated Biocompatible Theranostic Nanoagent for Targeted Multimodal Imaging and Photothermal Therapy
	Deng, Liming 1,2; Cai, Xiaojun 3; Sheng, Danli 1,2; Yang, Yang 1,2; Strohm, Eric M.; Wang, Zhigang 1,2; Ran, Haitao 1,2; Wang, Dong 5; Zheng, Yuanyi 1,2; Li, Pan 1,2
刊名	THERANOSTICS
	2017
卷号	7 期号:18 页码:4410
ISSN号	1838-7640
DOI	10.7150/thno.21283
英文摘要	Multifunctional nanoparticles have been reported for cancer detection and treatment currently. However, the accurate diagnosis and efficient treatment for tumors are still not satisfied. Here we report on the development of targeted phase change multimodal polymeric nanoparticles for the imaging and treatment of HER2-positive breast cancer. Methods: We evaluated the multimodal imaging capabilities of the prepared nanoparticles in vitro using agar-based phantoms. The targeting performance and cytotoxicity of the nanoparticles were examined in cell culture using SKBR3 (over-expressing HER2) and MDA-MB-231 (HER2 negative) cells. We then tested the magnetic resonance (MR)/photoacoustic (PA)/ultrasound (US)/near-infrared fluorescence (NIRF) multimodal imaging properties and photothermal effect of the nanoparticles in vivo using a SKBR3 breast xenograft model in nude mice. Tissue histopathology and immunofluorescence were also conducted. Results: Both in vitro and in vivo systematical studies validated that the hybrid nanoparticles can be used as a superb MR/US/PA/NIRF contrast agent to simultaneously diagnose and guide tumor photothermal therapy (PTT). When irradiated by a near infrared laser, the liquid PFP vaporizes to a gas, rapidly expelling the contents and damaging surrounding tissues. The resulting micro-sized bubbles provide treatment validation through ultrasound imaging. Localization of DIR and SPIO in the tumor region facilitate photothermal therapy for targeted tumor destruction. The mice treated with HER2 targeted nanoparticles had a nearly complete response to treatment, while the controls showed continued tumor growth. Conclusion: This novel theranostic agent may provide better diagnostic imaging and therapeutic potential than current methods for treating HER2-positive breast cancer.
WOS记录号	WOS:000413224300006
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26689]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China 2.Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China 3.Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 20050, Peoples R China 5.Strohm, Eric M.] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON M5S 2E8, Canada 6.Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, Chongqing 400016, Peoples R China
推荐引用方式 GB/T 7714	Deng, Liming,Cai, Xiaojun,Sheng, Danli,et al. A Laser-Activated Biocompatible Theranostic Nanoagent for Targeted Multimodal Imaging and Photothermal Therapy[J]. THERANOSTICS,2017,7(18):4410.
APA	Deng, Liming.,Cai, Xiaojun.,Sheng, Danli.,Yang, Yang.,Strohm, Eric M..,...&Sun, Yang.(2017).A Laser-Activated Biocompatible Theranostic Nanoagent for Targeted Multimodal Imaging and Photothermal Therapy.THERANOSTICS,7(18),4410.
MLA	Deng, Liming,et al."A Laser-Activated Biocompatible Theranostic Nanoagent for Targeted Multimodal Imaging and Photothermal Therapy".THERANOSTICS 7.18(2017):4410.