Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1

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	Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1
	Schnittger, Arp; Dissmeyer, Nico; Weimer, Annika K.; Pusch, Stefan; De Schutter, Kristof; Kamei, Claire Lessa Alvim; Nowack, Moritz K.; Novak, Bela; Duan, Gui-Lan; Zhu, Yong-Guan
刊名	PLANT CELL
	2009-11
卷号	21 期号:11 页码:3641-3654
英文摘要	Entry into mitosis is universally controlled by cyclin-dependent kinases (CDKs). A key regulatory event in metazoans and fission yeast is CDK activation by the removal of inhibitory phosphate groups in the ATP binding pocket catalyzed by Cdc25 phosphatases. In contrast with other multicellular organisms, we show here that in the flowering plant Arabidopsis thaliana, cell cycle control does not depend on sudden changes in the phosphorylation pattern of the PSTAIRE-containing Cdk1 homolog CDKA;1. Consistently, we found that neither mutants in a previously identified CDC25 candidate gene nor plants in which it is overexpressed display cell cycle defects. Inhibitory phosphorylation of CDKs is also the key event in metazoans to arrest cell cycle progression upon DNA damage. However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1. These observations reveal a surprising degree of divergence in the circuitry of highly conserved core cell cycle regulators in multicellular organisms. Based on biomathematical simulations, we propose a plant-specific model of how progression through the cell cycle could be wired in Arabidopsis.
WOS记录号	WOS:000273235600020
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/21781]
专题	生态环境研究中心_土壤环境科学实验室
推荐引用方式 GB/T 7714	Schnittger, Arp,Dissmeyer, Nico,Weimer, Annika K.,et al. Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1[J]. PLANT CELL,2009,21(11):3641-3654.
APA	Schnittger, Arp.,Dissmeyer, Nico.,Weimer, Annika K..,Pusch, Stefan.,De Schutter, Kristof.,...&De Veylder, Lieven.(2009).Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1.PLANT CELL,21(11),3641-3654.
MLA	Schnittger, Arp,et al."Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1".PLANT CELL 21.11(2009):3641-3654.