A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer
	Hu, Yanyan; Chi, Chongwei; Wang, Shunhao; Wang, Lingxiong; Liang, Ping; Liu, Fangyi; Shang, Wenting; Wang, Weiwei; Zhang, Fengrong; Li, Shanshan
刊名	ADVANCED MATERIALS
	2017
卷号	29 期号:33 页码:-
关键词	Active Targeting Clinical Intervention Gold Nanoshells Interventional Photothermal Therapy Pancreatic Cancer
英文摘要	Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (I-125) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39233]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Hu, Yanyan,Chi, Chongwei,Wang, Shunhao,et al. A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer[J]. ADVANCED MATERIALS,2017,29(33):-.
APA	Hu, Yanyan.,Chi, Chongwei.,Wang, Shunhao.,Wang, Lingxiong.,Liang, Ping.,...&Tian, Jie.(2017).A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer.ADVANCED MATERIALS,29(33),-.
MLA	Hu, Yanyan,et al."A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer".ADVANCED MATERIALS 29.33(2017):-.