An intracellular diamine oxidase triggered hyperpolarized Xe-129 magnetic resonance biosensor

doi:10.1039/c8cc07822j

	An intracellular diamine oxidase triggered hyperpolarized Xe-129 magnetic resonance biosensor
	Zhou, Xin; Ye, Chaohui; Liu, Maili; Yang, Yunhuang; Jiang, Weiping; Yuan, Yaping; Zhao, Longhui; Zeng, QingBin; Zhang, Xiaoxiao; Luo, Qing
刊名	CHEMICAL COMMUNICATIONS
	2018-12-18
卷号	54 期号:97 页码:5
ISSN号	1359-7345
DOI	10.1039/c8cc07822j
英文摘要	Here, a novel method was developed for suppressing Xe-129 signals in cucurbit[6]uril (CB6) until the trigger is activated by a specific enzyme. Due to its noncovalent interactions with amino-groups and CB6, putrescine dihydrochloride (Put) was chosen for blocking interactions between Xe-129 and CB6. Upon adding diamine oxidase (DAO), Put was released from CB6 and a Xe-129@CB6 Hyper-CEST signal emerged. This proposed Xe-129 biosensor was then tested in small intestinal villus epithelial cells.
WOS关键词	FLUORESCENT DYE DISPLACEMENT ; HOST-GUEST COMPLEXATION ; ENZYME-ACTIVITY ; SATURATION-TRANSFER ; CONTRAST AGENT ; PARACEST MRI ; DAO ACTIVITY ; NMR ; XENON ; PH
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000452111000004
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/13442]
专题	中国科学院武汉物理与数学研究所
通讯作者	Zhou, Xin
作者单位	Huazhong Univ Sci & Technol, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Chinese Acad Sci,Wuhan Natl Lab Optoelect, Wuhan 430071, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Xin,Ye, Chaohui,Liu, Maili,et al. An intracellular diamine oxidase triggered hyperpolarized Xe-129 magnetic resonance biosensor[J]. CHEMICAL COMMUNICATIONS,2018,54(97):5.
APA	Zhou, Xin.,Ye, Chaohui.,Liu, Maili.,Yang, Yunhuang.,Jiang, Weiping.,...&Zhang, Bin.(2018).An intracellular diamine oxidase triggered hyperpolarized Xe-129 magnetic resonance biosensor.CHEMICAL COMMUNICATIONS,54(97),5.
MLA	Zhou, Xin,et al."An intracellular diamine oxidase triggered hyperpolarized Xe-129 magnetic resonance biosensor".CHEMICAL COMMUNICATIONS 54.97(2018):5.