Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats | |
Alizamini, Mirmohammadali Mirramezani1,2,3; Kavianpour, Mohadeseh1; Karimi-Haghighi, Saeideh1; Fatahi, Zahra1; Haghparast, Abbas1 | |
刊名 | PEPTIDES |
2018-12-01 | |
卷号 | 110页码:40-46 |
关键词 | Reward Orexin CA1 region of the hippocampus Reinstatement Conditioned place preference Rat |
ISSN号 | 0196-9781 |
DOI | 10.1016/j.peptides.2018.10.011 |
产权排序 | 2 |
文献子类 | article |
英文摘要 | It has been shown that the hippocampus plays an essential role in the regulation of reward and memory as indicated by the conditioned place preference (CPP) paradigm. Morphine-induced CPP is a common method to consider motivational properties of morphine in animals. Recently, this model has been used in many laboratories to investigate neuronal mechanisms underlying reinstatement of morphine seeking induced by drug reexposure. Our previous studies indicate that the hippocampus especially CA1 region is involved in reinstatement of drug-seeking behaviors. Also, several studies have shown that orexin attenuates key functional and behavioral effects of its co-transmitter dynorphin. The present study evaluates the role of orexinergic receptors within the CA1 region of the hippocampus in the reinstatement of morphine-induced CPP. Therefore, after the extinction period, the different doses (SB 334867; 0.3, 3, and 30 nM/0.5 mu l DMSO) of either orexin-1 or -2 receptor antagonists were bilaterally microinjected into the CA1, 15 min before receiving an effective priming dose of morphine (1 mg/kg). The results revealed that administration of both SB 334867 and TCS OX2 29 prior to injection of the priming dose of morphine significantly reduced the reinstatement of morphine-induced CPP without altering the animal's locomotor activity. Also, the 50% effective dose value of SB 334867 on the reinstatement of morphine seeking behavior was close three times more than that in TCS OX2 29 treatment group. Therefore, the consequences suggested that both orexin receptors in the CA1 play a considerable role in the reinstatement of morphine-induced CPP. |
WOS关键词 | PRIMING-INDUCED REINSTATEMENT ; CONDITIONED PLACE PREFERENCE ; D2-LIKE DOPAMINE-RECEPTORS ; VENTRAL TEGMENTAL AREA ; CA1 REGION ; NUCLEUS-ACCUMBENS ; DENTATE GYRUS ; HIPPOCAMPUS ; ACQUISITION ; EXPRESSION |
WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE INC |
WOS记录号 | WOS:000451996300006 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/27813] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Haghparast, Abbas |
作者单位 | 1.Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Sch Med, POB 19615-1178, Tehran, Iran 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Alizamini, Mirmohammadali Mirramezani,Kavianpour, Mohadeseh,Karimi-Haghighi, Saeideh,et al. Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats[J]. PEPTIDES,2018,110:40-46. |
APA | Alizamini, Mirmohammadali Mirramezani,Kavianpour, Mohadeseh,Karimi-Haghighi, Saeideh,Fatahi, Zahra,&Haghparast, Abbas.(2018).Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats.PEPTIDES,110,40-46. |
MLA | Alizamini, Mirmohammadali Mirramezani,et al."Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats".PEPTIDES 110(2018):40-46. |
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