Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout | |
Tu, Hung-Pin1,2; Ko, Albert Min-Shan3; Lee, Su-Shin4; Lee, Chi-Pin5; Kuo, Tzer-Min5; Huang, Chung-Ming6,7; Ko, Ying-Chin5 | |
刊名 | JOURNAL OF HUMAN GENETICS
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2018 | |
卷号 | 63期号:1页码:63-70 |
ISSN号 | 1434-5161 |
DOI | 10.1038/s10038-017-0368-9 |
文献子类 | Article |
英文摘要 | We investigated the interactions of ALPK1 variants and the loci of ABCG2, SLC2A9, and SLC22A12 on gout risk. We conducted two case-control studies. Participants were recruited from hospitals (n = 410; 104 gout cases and 306 controls) and communities (n = 678; 373 gout cases and 305 controls) in Taiwan. The genotypes of ALPK1 (rs11726117 M861T, rs231247 R1084R, and rs231253 3' UTR), ABCG2 (rs2231142 Q141K and rs2231137 V12M), SLC2A9 (rs3733591 R265H and rs1014290), and SLC22A12 (rs3825016 H86H, rs11231825 H142H, and rs475688) were genotyped. Under a recessive model, the joint effects of ALPK1 variants and the SNPs rs2231142 of ABCG2, rs1014290 of SLC2A9, or rs475688 and rs3825016 of SLC22A12 were associated with gout. The rs11726117 [CC] of ALPK1 and rs2231142 [TT] of ABCG2 with the sequential addition of the rs1014290 [AA] of SLC2A9 and rs3825016 [CC] of SLC22A12 were associated with gout risk (odds ratio (OR): 13.01, 15.11, and 55.00 and positive predictive value (PPV): 56%, 69%, and 99% in the Han group, respectively; OR: 3.76, 5.78, and 12.30 and PPV: 74%, 80%, and 81% in the aboriginal group, respectively). Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout. |
WOS关键词 | GENOME-WIDE ASSOCIATION ; URIC-ACID ; MOLECULAR PHYSIOLOGY ; HYPERURICEMIA ; RISK ; POPULATION ; IDENTIFICATION ; EXCRETION ; ARTHRITIS ; LOCI |
WOS研究方向 | Genetics & Heredity |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000419977800008 |
资助机构 | Ministry of Science and Technology(MOST 105-2632-B-039-001 ; China Medical University(CMU105-S-01 ; Kaohsiung Medical University Research Foundation(KMU-M106006) ; MOST 106-2314-B-037-034) ; CMU105-S-03 ; CMU105-S-04 ; CMU105-S-06 ; DMR-106-115) |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.205/handle/311034/8713] ![]() |
专题 | 中国科学院古脊椎动物与古人类研究所 |
通讯作者 | Ko, Ying-Chin |
作者单位 | 1.Kaohsiung Med Univ, Coll Med, Sch Med, Dept Publ Hlth & Environm Med, Kaohsiung, Taiwan 2.Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan 3.Chinese Acad Sci, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 4.Kaohsiung Med Univ Hosp, Dept Surg, Div Plast Surg, Kaohsiung, Taiwan 5.China Med Univ, China Med Univ Hosp, Environment Omics Dis Res Ctr, Taichung 40402, Taiwan 6.China Med Univ Hosp, Dept Internal Med, Div Rheumatol & Immunol, Taichung 404, Taiwan 7.China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan |
推荐引用方式 GB/T 7714 | Tu, Hung-Pin,Ko, Albert Min-Shan,Lee, Su-Shin,et al. Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout[J]. JOURNAL OF HUMAN GENETICS,2018,63(1):63-70. |
APA | Tu, Hung-Pin.,Ko, Albert Min-Shan.,Lee, Su-Shin.,Lee, Chi-Pin.,Kuo, Tzer-Min.,...&Ko, Ying-Chin.(2018).Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout.JOURNAL OF HUMAN GENETICS,63(1),63-70. |
MLA | Tu, Hung-Pin,et al."Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout".JOURNAL OF HUMAN GENETICS 63.1(2018):63-70. |
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