A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy | |
Zhang, Guilong1; Du, Ruohong2; Qian, Junchao3; Zheng, Xiaojia2; Tian, Xiaohe4; Cai, Dongqing1; He, Jiacai2; Wu, Yiqun5; Huang, Wei5; Wang, Yuanyin2 | |
刊名 | NANOSCALE |
2018-01-07 | |
卷号 | 10期号:1页码:488-498 |
ISSN号 | 2040-3364 |
DOI | 10.1039/c7nr07957e |
英文摘要 | Considering the chemical exchange between gadolinium centers and water protons, nanosystems comprising gadolinium conjugated with high specific area nanocarriers might serve as more robust clinical tools for diagnosis and imaging-guided therapy. Herein, a pH-responsive nanosystem containing graphene oxide conjugated with a folic acid-and gadolinium-labeled dendrimer (FA-GCGLD) to boost its T1 contrast ability was developed, and doxorubicin (DOX) and colchicine (COLC) were efficiently loaded onto this nanosystem (FA-GCGLD-DOX/COLC). This nanosystem showed a prominent T1 contrast with an ultrahigh relaxivity of up to 11.6 mM(-1) s(-1) and pH-responsive drug release behavior. HepG2 cells treated with FA-GCGLD-DOX/COLC were efficiently inhibited, and the cell contrast was enhanced. In vivo, the tumor accumulation of FA-GCGLD-DOX/COLC significantly increased, thereby facilitating the systemic delivery of particles and exerting tumor growth inhibition and an enhanced tumor contrast effect. Moreover, compared to free drugs, FA-GCGLD-DOX/COLC effectively decreased the drug resistance of the tumor, thereby improving the cancer chemotherapeutic efficacy. In addition, injecting rats with FA-GCGLD afforded excellent magnetic resonance angiography (MRA) images with high-resolution vascular structures because of the long blood circulation time of FA-GCGLD. Thus, this study provides a powerful tool for diverse applications in the biomedical field, including accurate diagnosis and chemotherapy of tumors and the detection of cardiovascular diseases. |
资助项目 | National Natural Science Foundation of China[21407151] ; National Natural Science Foundation of China[31370983] ; National Natural Science Foundation of China[81371114] ; National Natural Science Foundation of China[81271162] ; Chinese Academy of Sciences[KSZD-EW-Z-022-05] ; Chinese Academy of Sciences[KFJ-STS-ZDTP-002] ; Chinese Academy of Sciences[KFJ-SW-STS-143] ; Chinese Academy of Sciences[2015385] ; Science and Technology Project of Anhui Province[1604a0802082] ; Science and Technology Project of Anhui Province[1401045013] ; Anhui Province Funds for Distinguished Young Scientists[1508085J08] ; Key Projects of the Outstanding Young Talents in Colleges and Universities[gxyqZD2016058] ; Foundation of Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine[2015-05] |
WOS关键词 | DRUG-DELIVERY SYSTEM ; WALLED CARBON NANOTUBES ; MRI CONTRAST AGENTS ; GRAPHENE OXIDE ; CANCER-CELLS ; GADOLINIUM ; NANOPARTICLES ; THERAPY ; THERANOSTICS ; DOXORUBICIN |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000418621000051 |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/34925] |
专题 | 合肥物质科学研究院_技术生物与农业工程研究所 |
通讯作者 | Zou, Duohong; Wu, Zhengyan |
作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China 2.Anhui Med Univ, Key Lab Oral Dis Res Anhui Prov, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Hefei 230032, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 4.Anhui Univ, Sch Life Sci, Hefei 230601, Anhui, Peoples R China 5.Shanghai Jiao Tong Univ, Natl Clin Res Ctr Stomatol, Shanghai Key Lab Stomatol, Dept Oral Surg,Natl Clin Res Ctr Stomatol, Shanghai 200001, Peoples R China 6.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Guilong,Du, Ruohong,Qian, Junchao,et al. A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy[J]. NANOSCALE,2018,10(1):488-498. |
APA | Zhang, Guilong.,Du, Ruohong.,Qian, Junchao.,Zheng, Xiaojia.,Tian, Xiaohe.,...&Wu, Zhengyan.(2018).A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy.NANOSCALE,10(1),488-498. |
MLA | Zhang, Guilong,et al."A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy".NANOSCALE 10.1(2018):488-498. |
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