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	Photosensitive nanoparticles combining vascular-independent intratumor distribution and on-demand oxygen-depot delivery for enhanced cancer photodynamic therapy
	Zhao, Caiyan1,2,3; Tong, Yujia1,2; Li, Xianlei1,2,3; Shao, Leihou1,2,3; Chen, Long1,2,3; Lu, Jianqing1,2; Deng, Xiongwei1,2; Wang, Xuan1,2,3; Wu, Yan1,2,3
刊名	Small
	2018-03-22
卷号	14期号:12页码:11
关键词	Hypoxia Perfluorooctyl bromide Photodynamic therapy Poly(ethylene glycol)-poly(epsilon-caprolactone) Tumor perfusion
ISSN号	1613-6810
DOI	10.1002/smll.201703045
通讯作者	Wu, yan(wuy@nanoctr.cn)
英文摘要	In drug delivery, the poor tumor perfusion results in disappointing therapeutic efficacy. nanomedicines for photodynamic therapy (pdt) greatly need deep tumor penetration due to short lifespan and weak diffusion of the cytotoxic reactive oxygen species (ros). the damage of only shallow cells can easily cause invasiveness and metastasis. moreover, even if the nanomedicines enter into deeper lesion, the effectiveness of pdt is limited due to the hypoxic microenvironment. here, a deep penetrating and oxygen self-sufficient pdt nanoparticle is developed for balanced ros distribution within tumor and efficient cancer therapy. the designed nanoparticles (cnps/ip) are doubly emulsified (w/o/w) from poly(ethylene glycol)-poly(epsilon-caprolactone) copolymers doped with photosensitizer ir780 in the o layer and oxygen depot perfluorooctyl bromide (pfob) inside the core, and functionalized with the tumor penetrating peptide cys-arg-gly-asp-lys (crgdk). the crgdk modification significantly improves penetration depth of cnps/ip and makes the cnps/ip arrive at both the periphery and hypoxic interior of tumors where the pfob releases oxygen, effectively alleviating hypoxia and guaranteeing efficient pdt performance. the improved intratumoral distribution of photosensitizer and adequate oxygen supply augment the sensitivity of tumor cells to pdt and significantly improve pdt efficiency. such a nanosystem provides a potential platform for improved therapeutic index in anticancer therapy.
WOS关键词	IN-VIVO ; COPOLYMER MICELLES ; TUMOR OXYGENATION ; DRUG-RELEASE ; HYPOXIA ; PERMEABILITY ; PENETRATION ; COMBINATION ; RESISTANCE ; PACLITAXEL
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000428344300010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178133
专题	高能物理研究所
通讯作者	Wu, Yan
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Caiyan,Tong, Yujia,Li, Xianlei,et al. Photosensitive nanoparticles combining vascular-independent intratumor distribution and on-demand oxygen-depot delivery for enhanced cancer photodynamic therapy[J]. Small,2018,14(12):11.
APA	Zhao, Caiyan.,Tong, Yujia.,Li, Xianlei.,Shao, Leihou.,Chen, Long.,...&Wu, Yan.(2018).Photosensitive nanoparticles combining vascular-independent intratumor distribution and on-demand oxygen-depot delivery for enhanced cancer photodynamic therapy.Small,14(12),11.
MLA	Zhao, Caiyan,et al."Photosensitive nanoparticles combining vascular-independent intratumor distribution and on-demand oxygen-depot delivery for enhanced cancer photodynamic therapy".Small 14.12(2018):11.

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