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	Exposure to alumina nanoparticles in female mice during pregnancy induces neurodevelopmental toxicity in the offspring
	Zhang, Qinli1,2; Ding, Yong1,5; He, Kaihong1; Li, Huan1; Gao, Fuping3; Moehling, Taylor J.2; Wu, Xiaohong1; Duncan, Jeremy4; Niu, Qiao1
刊名	Frontiers in pharmacology
	2018-03-20
卷号	9页码:12
关键词	Alumina nanoparticles Developmental neurotoxicity Neurodevelopmental toxicity Oxidative stress Neurotransmitter
ISSN号	1663-9812
DOI	10.3389/fphar.2018.00253
通讯作者	Zhang, qinli(zhangql9306111@gmail.com)
英文摘要	Alumina nanoparticles (alnp) have been shown to accumulate in organs and penetrate biological barriers which lead to toxic effects in many organ systems. however, it is not known whether alnp exposure to female mice during pregnancy can affect the development of the central nervous system or induce neurodevelopmental toxicity in the offspring. the present study aims to examine the effect of alnp on neurodevelopment and associated underlying mechanism. icr strain adult female mice were randomly divided into four groups, which were treated with normal saline (control), 10 mu m particle size of alumina (bulk-al), and 50 and 13 nm alnp during entire pregnancy period. aluminum contents in the hippocampus of newborns were measured and neurodevelopmental behaviors were tracked in the offspring from birth to 1 month of age. furthermore, oxidative stress and neurotransmitter levels were measured in the cerebral cortex of the adolescents. our results showed that aluminum contents in the hippocampus of newborns in alnp-treated groups were significantly higher than those in bulk-al and controls. moreover, the offspring delivered by alnp-treated female mice displayed stunted neurodevelopmental behaviors. finally, the offspring of alnp-treated mice demonstrated significantly increased anxiety-like behavior with impaired learning and memory performance at 1 month of age. the underlying mechanism could be related to increased oxidative stress and decreased neurotransmitter levels in the cerebral cortex. we therefore conclude that alnp exposure of female mice during pregnancy can induce neurodevelopmental toxicity in offspring.
WOS关键词	ZINC-OXIDE NANOPARTICLES ; OXIDATIVE STRESS ; SILVER NANOPARTICLES ; TITANIUM-DIOXIDE ; IN-VIVO ; DEVELOPMENTAL EXPOSURE ; EMBRYONIC-DEVELOPMENT ; AL2O3 NANOPARTICLES ; ZEBRAFISH EMBRYOS ; CARBON NANOTUBES
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000427863800001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178090
专题	高能物理研究所
通讯作者	Zhang, Qinli
作者单位	1.Shanxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth, Taiyuan, Shanxi, Peoples R China 2.Univ Mississippi, Med Ctr, Dept Pathol, Jackson, MS 39216 USA 3.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China 4.Univ Mississippi, Med Ctr, Dept Physiol, Jackson, MS 39216 USA 5.Shaanxi Prov Ctr Dis Control & Prevent, Xian, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qinli,Ding, Yong,He, Kaihong,et al. Exposure to alumina nanoparticles in female mice during pregnancy induces neurodevelopmental toxicity in the offspring[J]. Frontiers in pharmacology,2018,9:12.
APA	Zhang, Qinli.,Ding, Yong.,He, Kaihong.,Li, Huan.,Gao, Fuping.,...&Niu, Qiao.(2018).Exposure to alumina nanoparticles in female mice during pregnancy induces neurodevelopmental toxicity in the offspring.Frontiers in pharmacology,9,12.
MLA	Zhang, Qinli,et al."Exposure to alumina nanoparticles in female mice during pregnancy induces neurodevelopmental toxicity in the offspring".Frontiers in pharmacology 9(2018):12.

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