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	Application of multifunctional nanomaterials in tumor radiosensitization
	Gong Linji1,3; Xie Jiani1,3; Zhu Shuang1; Gu Zhanjun1,3; Zhao Yuliang1,2,3
刊名	Acta physico-chimica sinica
	2018
卷号	34期号:2页码:140-167
关键词	Radiation therapy Nanoradiosensitizer Radiosensitization mechanism Nanomedicine
ISSN号	1000-6818
DOI	10.3866/pku.whxb201707174
通讯作者	Gu zhanjun(zjgu@ihep.ac.cn) ; Zhao yuliang(zhaoyl@nanoctr.cn)
英文摘要	Radiation therapy kills tumor cells via focused high energy radiation, and has become one of the most common and effective clinical treatments for malignant tumors. however, some limitations restrict its clinical efficacy, including a requirement for elevated doses of radiation, side effects due to exposure of healthy tissue, and especially radioresistance of tumor cells. with the development of nanomedicine, multifunctional nanoradiosensitizers offer a new route to improve the efficiency of radiation therapy. in this paper, we summarize the main types of nanoradiosensitizers and their applications in radiation therapy, especially those that have currently entered clinical trials. we also summarize the main approaches to nanomaterials-based radiosensitization, and discuss the factors influencing their application. finally, the challenges and prospects of multifunctional nanoradiosensitizers are presented.
WOS关键词	GADOLINIUM-BASED NANOPARTICLES ; IRON-OXIDE NANOPARTICLES ; CANCER RADIATION-THERAPY ; RAY COMPUTED-TOMOGRAPHY ; MESOPOROUS SILICA NANOPARTICLES ; RADIO-PHOTOTHERMAL THERAPY ; METAL-BASED NANOPARTICLES ; WALLED CARBON NANOTUBES ; NEAR-INFRARED WINDOW ; ONE-POT SYNTHESIS
WOS研究方向	Chemistry
WOS类目	Chemistry, Physical
语种	英语
出版者	PEKING UNIV PRESS
WOS记录号	WOS:000423693100007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177931
专题	高能物理研究所
通讯作者	Gu Zhanjun; Zhao Yuliang
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Gong Linji,Xie Jiani,Zhu Shuang,et al. Application of multifunctional nanomaterials in tumor radiosensitization[J]. Acta physico-chimica sinica,2018,34(2):140-167.
APA	Gong Linji,Xie Jiani,Zhu Shuang,Gu Zhanjun,&Zhao Yuliang.(2018).Application of multifunctional nanomaterials in tumor radiosensitization.Acta physico-chimica sinica,34(2),140-167.
MLA	Gong Linji,et al."Application of multifunctional nanomaterials in tumor radiosensitization".Acta physico-chimica sinica 34.2(2018):140-167.

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