| Nanomicelle-assisted targeted ocular delivery with enhanced antiinflammatory efficacy in vivo | |
| Weng, Yu-Hua1,2,3; Ma, Xiao-Wei1,2; Che, Jing1,2,3; Li, Chan1,2; Liu, Juan1,2; Chen, Shi-Zhu1,2; Wang, Yu-Qin4,5; Gan, Ya-Ling1,2; Chen, Hao4,5; Hu, Zhong-Bo3 | |
| 刊名 | Advanced science
 |
| 2018 | |
| 卷号 | 5期号:1页码:11 |
| 关键词 | Antiinflammation Flurbiprofen nanomicelles Functional peptide Ocular delivery system |
| ISSN号 | 2198-3844 |
| DOI | 10.1002/advs.201700455 |
| 通讯作者 | Hu, zhong-bo(huzq@ucas.ac.cn) ; Nan, kai-hui(nankh@163.com) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Ocular inflammations are common diseases that may lead to serious vision-threatening obstacles. eye drops for antiinflammation therapy need to be administered multiple times daily at a high dosage due to the rapid precorneal removal and low bioavailability of drugs. to overcome these problems, a crgd-functionalized dspe-peg(2000) nanomicelle (dspe-peg(2000)-crgd) encapsulated with flurbiprofen is proposed. the tailored nanomicelles trigger specific binding to integrin receptors on the ocular surface, which leads to rapid and robust mucoadhesion, superior ocular surface retention, and transcorneal penetration behaviors of nanomicelles. due to the enhanced drug delivery on ocular surface and in aqueous humor, the functionalized nanoformulation significantly improves ocular antiinflammation efficacy at a low dosage by blocking the synthesis of inflammatory mediators and cytokines. the present study demonstrates a promising strategy that uses a functional peptide combined with nanomicelles for targeted delivery to the eye in ophthalmologic applications. |
| WOS关键词 | DRUG-DELIVERY ; CONJUNCTIVAL EPITHELIA ; CORNEAL ; CELLS ; NANOPARTICLES ; FORMULATION ; UVEITIS ; INFLAMMATION ; TRANSITION ; MICELLES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000422658700015 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2177911 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Hu, Zhong-Bo; Nan, Kai-Hui; Liang, Xing-Jie |
| 作者单位 | 1.Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 4.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Wenzhou, Peoples R China 5.Wenzhou Med Univ, Eye Hosp, Wenzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Weng, Yu-Hua,Ma, Xiao-Wei,Che, Jing,et al. Nanomicelle-assisted targeted ocular delivery with enhanced antiinflammatory efficacy in vivo[J]. Advanced science,2018,5(1):11. |
| APA | Weng, Yu-Hua.,Ma, Xiao-Wei.,Che, Jing.,Li, Chan.,Liu, Juan.,...&Liang, Xing-Jie.(2018).Nanomicelle-assisted targeted ocular delivery with enhanced antiinflammatory efficacy in vivo.Advanced science,5(1),11. |
| MLA | Weng, Yu-Hua,et al."Nanomicelle-assisted targeted ocular delivery with enhanced antiinflammatory efficacy in vivo".Advanced science 5.1(2018):11. |
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