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	Differential pd-nanocrystal facets demonstrate distinct antibacterial activity against gram-positive and gram-negative bacteria
	Fang, Ge1; Li, Weifeng1; Shen, Xiaomei2; Perez-Aguilar, Jose Manuel3; Chong, Yu1; Gao, Xingfa2; Chai, Zhifang1; Chen, Chunying4,5,6; Ge, Cuicui1; Zhou, Ruhong1,3,7
刊名	Nature communications
	2018-01-09
卷号	9页码:9
ISSN号	2041-1723
DOI	10.1038/s41467-017-02502-3
通讯作者	Chen, chunying(chenchy@nanoctr.cn) ; Ge, cuicui(ccge@suda.edu.cn) ; Zhou, ruhong(ruhongz@us.ibm.com)
英文摘要	Noble metal-based nanomaterials have shown promise as potential enzyme mimetics, but the facet effect and underlying molecular mechanisms are largely unknown. herein, with a combined experimental and theoretical approach, we unveil that palladium (pd) nanocrystals exhibit facet-dependent oxidase and peroxidase-like activities that endow them with excellent antibacterial properties via generation of reactive oxygen species. the antibacterial efficiency of pd nanocrystals against gram-positive bacteria is consistent with the extent of their enzyme-like activity, that is {100}-faceted pd cubes with higher activities kill bacteria more effectively than {111}-faceted pd octahedrons. surprisingly, a reverse trend of antibacterial activity is observed against gram-negative bacteria, with pd octahedrons displaying stronger penetration into bacterial membranes than pd nanocubes, thereby exerting higher antibacterial activity than the latter. our findings provide a deeper understanding of facet-dependent enzyme-like activities and might advance the development of noble metal-based nanomaterials with both enhanced and targeted antibacterial activities.
收录类别	SCI
WOS关键词	ANTIMICROBIAL AGENTS ; GOLD NANOPARTICLES ; ESCHERICHIA-COLI ; PALLADIUM NANOCRYSTALS ; SILVER NANOPARTICLES ; CATALYTIC-ACTIVITIES ; RESISTANT BACTERIA ; CARBON NANOTUBES ; ASCORBIC-ACID ; MECHANISM
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000419658100028
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177879
专题	高能物理研究所
通讯作者	Chen, Chunying; Ge, Cuicui; Zhou, Ruhong
作者单位	1.Soochow Univ, Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China 2.Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China 3.IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA 4.Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 5.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China 6.Chinese Acad Sci, Inst High Energy Phys, Beijing 100190, Peoples R China 7.Columbia Univ, Dept Chem, New York, NY 10027 USA
推荐引用方式 GB/T 7714	Fang, Ge,Li, Weifeng,Shen, Xiaomei,et al. Differential pd-nanocrystal facets demonstrate distinct antibacterial activity against gram-positive and gram-negative bacteria[J]. Nature communications,2018,9:9.
APA	Fang, Ge.,Li, Weifeng.,Shen, Xiaomei.,Perez-Aguilar, Jose Manuel.,Chong, Yu.,...&Zhou, Ruhong.(2018).Differential pd-nanocrystal facets demonstrate distinct antibacterial activity against gram-positive and gram-negative bacteria.Nature communications,9,9.
MLA	Fang, Ge,et al."Differential pd-nanocrystal facets demonstrate distinct antibacterial activity against gram-positive and gram-negative bacteria".Nature communications 9(2018):9.

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