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	Graphene oxide-iron oxide nanocomposite as an inhibitor of a beta 42 amyloid peptide aggregation
	Ahmad, Israr1; Mozhi, Anbu1; Yang, Lin1; Han, Qiusen1,2; Liang, Xingjie1; Li, Chan1; Yang, Rong1,2; Wang, Chen1
刊名	Colloids and surfaces b-biointerfaces
	2017-11-01
卷号	159页码:540-545
关键词	Graphene oxides Nanocomposites Amyloid peptide Aggregation
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2017.08.020
通讯作者	Yang, rong(yangr@nanoctr.cn) ; Wang, chen(wangch@nanoctr.cn)
英文摘要	Inhibiting amyloid beta (a beta) aggregation has drawn much attention because it is one of the main reasons for the cause of alzheimer's disease (ad). here we have synthesized a nanocomposite of graphene oxide iron oxide (goio) and demonstrated its ability of modulating ap aggregation. the inhibition effects of the goio nanocomposite on a beta aggregates was studied by thioflavin t fluorescence assay, circular dichroism and transmission electron microscopy, respectively. furthermore, the cell viability study revealed that the goio nanocomposite can reduce the toxicity of a beta fibrils to neuroblastoma cells. our results demonstrated that the combination of go and 10 as a nanocomposite material has a potential use for the design new therapeutic agents for the treatment of alzheimer's disease. (c) 2017 elsevier b.v. all rights reserved.
WOS关键词	ALZHEIMERS-DISEASE ; PROTEIN FIBRILLATION ; IN-VITRO ; NANOPARTICLES ; FIBRILLIZATION ; PATHOGENESIS ; HYPOTHESIS ; OLIGOMERS ; DEMENTIA ; KLVFF
WOS研究方向	Biophysics ; Chemistry ; Materials Science
WOS类目	Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000418729600062
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177817
专题	高能物理研究所
通讯作者	Yang, Rong; Wang, Chen
作者单位	1.Univ Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ahmad, Israr,Mozhi, Anbu,Yang, Lin,et al. Graphene oxide-iron oxide nanocomposite as an inhibitor of a beta 42 amyloid peptide aggregation[J]. Colloids and surfaces b-biointerfaces,2017,159:540-545.
APA	Ahmad, Israr.,Mozhi, Anbu.,Yang, Lin.,Han, Qiusen.,Liang, Xingjie.,...&Wang, Chen.(2017).Graphene oxide-iron oxide nanocomposite as an inhibitor of a beta 42 amyloid peptide aggregation.Colloids and surfaces b-biointerfaces,159,540-545.
MLA	Ahmad, Israr,et al."Graphene oxide-iron oxide nanocomposite as an inhibitor of a beta 42 amyloid peptide aggregation".Colloids and surfaces b-biointerfaces 159(2017):540-545.

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