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	Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells
	Hu, Kelei1,2; Zhou, Huige1; Liu, Ying1; Liu, Zhu1; Liu, Jing1; Tang, Jinglong1; Li, Jiayang1; Zhang, Jiakun1; Sheng, Wang2; Zhao, Yuliang1
刊名	Nanoscale
	2015
卷号	7期号:18页码:8607-8618
ISSN号	2040-3364
DOI	10.1039/c5nr01084e
通讯作者	Liu, ying(liuy@nanoctr.cn)
英文摘要	Cancer stem cells (cscs) have the ability to transform into bulk cancer cells, to promote tumor growth and establish tumor metastasis. to effectively inhibit tumor growth and prevent metastasis, treatments with conventional chemotherapy drugs should be combined with csc targeted drugs. in this study, we describe the synthesis and characterization of a new amphiphilic polymer, hyaluronic acid-cystamine-polylactic-co-glycolic acid (ha-ss-plga), composed of a hydrophobic plga head and a hydrophilic ha segment linked by a bioreducible disulfide bond. with a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (dox) and cyclopamine (cyc, a primary inhibitor of the hedgehog signaling pathway of cscs) to both a cd44-overexpressing breast csc subpopulation and bulk breast cancer cells and allow an on-demand release. the resulting drug-loaded nps exhibited a redox-responsive drug release profile. dual drug-loaded particles potently diminished the number and size of tumor-spheres and ha showed a targeting effect towards breast cscs. in vivo combination therapy further demonstrated a remarkable synergistic anti-tumor effect and prolonged survival compared to monotherapy using the orthotopic mammary fat pad tumor growth model. the co-delivery of drug and the csc specific inhibitor towards targeted cancer chemotherapeutics provides an insight into anticancer strategy with facile control and high efficacy.
WOS关键词	HEDGEHOG SIGNALING INHIBITOR ; GOLD NANORODS ; DRUG-DELIVERY ; NANOPARTICLES ; GLUTATHIONE ; METASTASIS ; THERAPY ; RELEASE ; COPOLYMER ; MICELLES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000354044600045
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177630
专题	高能物理研究所
通讯作者	Liu, Ying
作者单位	1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China 3.Collaborat Innovat Ctr Radiol Med Jiangsu Higher, Nanjing, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Hu, Kelei,Zhou, Huige,Liu, Ying,et al. Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells[J]. Nanoscale,2015,7(18):8607-8618.
APA	Hu, Kelei.,Zhou, Huige.,Liu, Ying.,Liu, Zhu.,Liu, Jing.,...&Chen, Chunying.(2015).Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells.Nanoscale,7(18),8607-8618.
MLA	Hu, Kelei,et al."Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells".Nanoscale 7.18(2015):8607-8618.

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