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	Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy
	Xuan, Mingjun1,2; Shao, Jingxin1,2; Zhao, Jie1; Li, Qi1,3; Dai, Luru2; Li, Junbai1,3
刊名	Angewandte chemie-international edition
	2018-05-22
卷号	57期号:21页码:6049-6053
关键词	Magnetic nanoparticles Mesoporous silica Photodynamic therapy Red blood cell membrane Singlet oxygen
ISSN号	1433-7851
DOI	10.1002/anie.201712996
通讯作者	Li, junbai(jbli@iccas.ac.cn)
英文摘要	Targeted drug delivery is an emerging technological strategy that enables nanoparticle systems to be responsive for tumor therapy. magnetic mesoporous silica nanoparticles (mmsns) were cloaked with red blood cell membrane (rbc). this integrates long circulation, photosensitizer delivery, and magnetic targeting for cancer therapy. invivo experiments demonstrate that rbc@mmsns can avoid immune clearance and achieve magnetic field (mf)-induced high accumulation in a tumor. when light irradiation is applied, singlet oxygen rapidly generates from hypocrellinb (hb)-loaded rbc@mmsn and leads to the necrosis of tumor tissue. such a rbc-cloaked magnetic nanocarrier effectively integrates immunological adjuvant, photosensitizer delivery, mf-assisted targeting photodynamic therapy, which provides an innovative strategy for cancer therapy.
WOS关键词	DRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; ERYTHROCYTE-MEMBRANE ; PHOTOTHERMAL THERAPY ; BIOMIMETIC NANOPARTICLES ; POLYMERIC NANOPARTICLES ; GOLD NANOCAGES ; PLATFORM ; NANOCARRIERS ; VACCINATION
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000432710100007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177516
专题	高能物理研究所
通讯作者	Li, Junbai
作者单位	1.Chinese Acad Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, BNLMS, Inst Chem, Beiyijie 2, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beiyitiao 11, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xuan, Mingjun,Shao, Jingxin,Zhao, Jie,et al. Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy[J]. Angewandte chemie-international edition,2018,57(21):6049-6053.
APA	Xuan, Mingjun,Shao, Jingxin,Zhao, Jie,Li, Qi,Dai, Luru,&Li, Junbai.(2018).Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy.Angewandte chemie-international edition,57(21),6049-6053.
MLA	Xuan, Mingjun,et al."Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy".Angewandte chemie-international edition 57.21(2018):6049-6053.

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