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	Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of mrsa
	Duan, Fei1; Feng, Xiaochen1; Jin, Yan1; Liu, Dawei1; Yang, Xinjian1; Zhou, Guoqiang1; Liu, Dandan1; Li, Zhenhua1; Liang, Xing-Jie2; Zhang, Jinchao1
刊名	Biomaterials
	2017-11-01
卷号	144页码:155-165
关键词	Metal-carbenicillin frameworks Co-delivery system Ph-responsive Enhance biofilm penetration Mrsa
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2017.08.024
通讯作者	Li, zhenhua(zhenhuali1013@163.com) ; Liang, xing-jie(liangxj@nanoctr.cn) ; Zhang, jinchao(jczhang6970@163.com)
英文摘要	The development of effective therapies to control methicillin-resistant staphylococcus aureus (mrsa) infections is challenging because antibiotics can be degraded by the production of certain enzymes, for example, beta-lactamases. additionally, the antibiotics themselves fail to penetrate the full depth of biofilms formed from extracellular polymers. nanoparticle-based carriers can deliver antibiotics with better biofilm penetration, thus combating bacterial resistance. in this study, we describe a general approach for the construction of beta-lactam antibiotics and beta-lactamase inhibitors co-delivery of nanoantibiotics based on metal-carbenicillin framework-coated mesoporous silica nanoparticles (msn) to overcome mrsa. carbenicillin, a beta-lactam antibiotic, was used as an organic ligand that coordinates with fe3+ to form a metal-carbenicillin framework to block the pores of the msn. furthermore, these beta-lactamase inhibitor loaded nanoantibiotics were stable under physiological conditions and could synchronously release antibiotic molecules and inhibitors at the bacterial infection site to achieve a better elimination of antibiotic resistant bacterial strains and biofilms. we confirmed that these beta-lactamase inhibitor-loaded nanoantibiotics had better penetration depth into biofilms and an obvious effect on the inhibition of mrsa both in vitro and in vivo. (c) 2017 published by elsevier ltd.
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; BETA-LACTAM ANTIBIOTICS ; PATHOGENIC BACTERIA ; INFECTIOUS-DISEASES ; QUANTUM DOTS ; BIOFILMS ; DELIVERY ; RESISTANT ; PERMEABILITY ; DISCOVERY
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000411420000014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177069
专题	高能物理研究所
通讯作者	Li, Zhenhua; Liang, Xing-Jie; Zhang, Jinchao
作者单位	1.Hebei Univ, Key Lab Med Chem & Mol Diag, Coll Chem & Environm Sci,Minist Educ, Analyt Chem Key Lab Hebei Prov,Chem Biol Key Lab, Baoding 071002, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Duan, Fei,Feng, Xiaochen,Jin, Yan,et al. Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of mrsa[J]. Biomaterials,2017,144:155-165.
APA	Duan, Fei.,Feng, Xiaochen.,Jin, Yan.,Liu, Dawei.,Yang, Xinjian.,...&Zhang, Jinchao.(2017).Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of mrsa.Biomaterials,144,155-165.
MLA	Duan, Fei,et al."Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of mrsa".Biomaterials 144(2017):155-165.

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