| Materials for microfluidic immunoassays: a review | |
| Mou, Lei1,2,3; Jiang, Xingyu1,2,3 | |
| 刊名 | Advanced healthcare materials
 |
| 2017-08-09 | |
| 卷号 | 6期号:15页码:20 |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201601403 |
| 通讯作者 | Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | Conventional immunoassays suffer from at least one of these following limitations: long processing time, high costs, poor user-friendliness, technical complexity, poor sensitivity and specificity. microfluidics, a technology characterized by the engineered manipulation of fluids in channels with characteristic lengthscale of tens of micrometers, has shown considerable promise for improving immunoassays that could overcome these limitations in medical diagnostics and biology research. the combination of microfluidics and immunoassay can detect biomarkers with faster assay time, reduced volumes of reagents, lower power requirements, and higher levels of integration and automation compared to traditional approaches. this review focuses on the materials-related aspects of the recent advances in micro-fluidics-based immunoassays for point-of-care (poc) diagnostics of biomarkers. we compare the materials for microfluidic chips fabrication in five aspects: fabrication, integration, function, modification and cost, and describe their advantages and drawbacks. in addition, we review materials for modifying antibodies to improve the performance of the reaction of immunoassay. we also review the state of the art in microfluidic immunoassays poc platforms, from the laboratory to routine clinical practice, and also commercial products in the market. finally, we discuss the current challenges and future developments in microfluidic immunoassays. |
| WOS关键词 | MEDIATED ISOTHERMAL AMPLIFICATION ; SURFACE-PLASMON RESONANCE ; BIO-NANO-CHIP ; ELECTROCHEMICAL DETECTION ; ULTRASENSITIVE DETECTION ; HORSERADISH-PEROXIDASE ; GOLD NANOPARTICLES ; DIAGNOSTIC DEVICES ; DISEASE DIAGNOSIS ; LOGIC GATES |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000407278100005 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2176956 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mou, Lei,Jiang, Xingyu. Materials for microfluidic immunoassays: a review[J]. Advanced healthcare materials,2017,6(15):20. |
| APA | Mou, Lei,&Jiang, Xingyu.(2017).Materials for microfluidic immunoassays: a review.Advanced healthcare materials,6(15),20. |
| MLA | Mou, Lei,et al."Materials for microfluidic immunoassays: a review".Advanced healthcare materials 6.15(2017):20. |
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