| Aggregation-induced emission: lighting up cells, revealing life! | |
| Wang, Yi-Feng1,3; Zhang, Tingbin1,2; Liang, Xing-Jie1,3 | |
| 刊名 | Small
 |
| 2016-12-21 | |
| 卷号 | 12期号:47页码:6451-6477 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201601468 |
| 通讯作者 | Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Understanding metabolism and dynamic biological events in cells, as well as physiological functions and pathological changes in organisms, is the major goal of biological investigations. it will improve our capability to diagnose and treat diseases, and will enhance personalized medicine. fluorescence imaging is a powerful tool that plays an essential role in acquiring the comprehensive knowledge necessary to help reach this goal. fluorescent molecules are crucial factors for obtaining high quality images. in contrast to conventional fluorogens with aggregation-caused quenching (acq) effect, molecules that show aggregation-induced emission (aie) effect open up new avenues for fluorescence imaging. so far, a large variety of aie probes have been developed and applied to bioimaging because of their outstanding characteristics, such as high fluorescence efficiency, excellent photostability and high signal-to-noise ratio (snr). in this review, recent advances in aie-based probes for biomedical imaging of intracellular microenvironments, natural macromolecules, subcellular organelles, intracellular processes, living tissues, and diagnosis and therapeutic evaluation of diseases in vivo are summarized. it is hoped that this review generates great research enthusiasm for aie-based bioimaging, in order to promote the development of promising aie probes and guide us to a better understanding of the biological essence of life. |
| WOS关键词 | BLOOD VASCULAR VISUALIZATION ; ULTRABRIGHT ORGANIC DOTS ; BLADDER-CANCER PATIENTS ; TURN-ON MANNER ; IN-VIVO ; REAL-TIME ; UP PROBE ; LIPID DROPLETS ; LIVING CELLS ; BIOCOMPATIBLE NANOPARTICLES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000393220700003 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2176840 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liang, Xing-Jie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China 2.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yi-Feng,Zhang, Tingbin,Liang, Xing-Jie. Aggregation-induced emission: lighting up cells, revealing life![J]. Small,2016,12(47):6451-6477. |
| APA | Wang, Yi-Feng,Zhang, Tingbin,&Liang, Xing-Jie.(2016).Aggregation-induced emission: lighting up cells, revealing life!.Small,12(47),6451-6477. |
| MLA | Wang, Yi-Feng,et al."Aggregation-induced emission: lighting up cells, revealing life!".Small 12.47(2016):6451-6477. |
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