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	Role of nanotechnology in hiv/aids vaccine development
	Liu, Ying; Chen, Chunying1
刊名	Advanced drug delivery reviews
	2016-08-01
卷号	103页码:76-89
关键词	Hiv/aids vaccine Nanotechnology Nano-carriers Vaccine adjuvant Immunological responses
ISSN号	0169-409X
DOI	10.1016/j.addr.2016.02.010
通讯作者	Chen, chunying(chenchy@nanoctr.cn)
英文摘要	Hiv/aids is one of the worst crises affecting global health and influencing economic development and social stability. preventing and treating hiv infection is a crucial task. however, there is still no effective hiv vaccine for clinical application. nanotechnology has the potential to solve the problems associated with traditional hiv vaccines. at present, various nano-architectures and nanomaterials can function as potential hiv vaccine carriers or adjuvants, including inorganic nanomaterials, liposomes, micelles and polymer nanomaterials. in this review, we summarize the current progress in the use of nanotechnology for the development of an hiv/aids vaccine and discuss its potential to greatly improve the solubility, permeability, stability and pharmacokinetics of hiv vaccines. although nanotechnology holds great promise for applications in hiv/aids vaccines, there are still many inadequacies that result in a variety of risks and challenges. the potential hazards to the human body and environment associated with some nano-carriers, and their underlying mechanisms require in-depth study. non-toxic or low toxic nanomaterials with adjuvant activity have been identified. however, studying the confluence of factors that affect the adjuvant activity of nanomaterials may be more important for the optimization of the dosage and immunization strategy and investigations into the exact mechanism of action. moreover, there are no uniform standards for investigations of nanomaterials as potential vaccine adjuvants. these limitations make it harder to analyze and deduce rules from the existing data. developing vaccine nano-carriers or adjuvants with high benefit-cost ratios is important to ensure their broad usage. despite some shortcomings, nanomaterials have great potential and application prospects in the fields of aids treatment and prevention. (c) 2016 elsevier b.v. all rights reserved.
WOS关键词	MEDIATED IMMUNE-RESPONSES ; T-CELL RESPONSES ; POLY(GAMMA-GLUTAMIC ACID) NANOPARTICLES ; IMMUNODEFICIENCY-VIRUS-INFECTION ; GOLD NANOPARTICLES ; PLA NANOPARTICLES ; DENDRITIC CELLS ; HIV-1 INFECTION ; AIDS VACCINE ; DNA VACCINE
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000380083700006
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176593
专题	高能物理研究所
通讯作者	Chen, Chunying
作者单位	1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ying,Chen, Chunying. Role of nanotechnology in hiv/aids vaccine development[J]. Advanced drug delivery reviews,2016,103:76-89.
APA	Liu, Ying,&Chen, Chunying.(2016).Role of nanotechnology in hiv/aids vaccine development.Advanced drug delivery reviews,103,76-89.
MLA	Liu, Ying,et al."Role of nanotechnology in hiv/aids vaccine development".Advanced drug delivery reviews 103(2016):76-89.

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