QQ客服 官方微博 反馈留言

	An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer
	Ji, Tianjiao1,2; Li, Suping1,2; Zhang, Yinlong1,2,4; Lang, Jiayan1,2; Ding, Yanping1,2; Zhao, Xiao3; Zhao, Ruifang1,2; Li, Yiye1,2; Shi, Jian1,2; Hao, Jihui3
刊名	Acs applied materials & interfaces
	2016-02-10
卷号	8期号:5页码:3438-3445
关键词	Mmp-2 responsive liposome Antifibrosis Pancreatic stellate cells Enhanced drug perfusion Pancreatic cancer
ISSN号	1944-8244
DOI	10.1021/acsami.5b11619
通讯作者	Li, suping(lisuping@nanoctr.cn) ; Zhao, ying(zhaoying@nanoctr.cn) ; Nie, guangjun(niegj@nanoctr.cn)
英文摘要	Fibrotic stroma, a critical character of pancreatic tumor microenvironment, provides a critical barrier against the penetration and efficacy of various antitumor drugs. therefore, new strategies are urgently needed to alleviate the fibrotic mass and increase the drug perfusion within pancreatic cancer tissue. in our current work, we developed a,beta-cydodextrin (beta-cd) modified matrix metalloproteinase-2 (mmp-2) responsive liposome, integrating antifibrosis and chemotherapeutic drugs for regulation of pancreatic stellate cells (pscs), a key source of the fibrosis, and targeted delivery of cytotoxic drugs for pancreatic cancer therapy. these liposomes disassembed into two functional parts upon mmp-2 cleavage at the tumor site. one part was constituted by the beta-cds and the antifibrosis drug pirfenidone, which was kept in the stroma and inhibited the expression of collagen i and tgf-beta in pscs, down-regulating the fibrosis and decreasing the stromal barrier. the other segment, the rgd peptide-modified-liposome loading the chemotherapeutic drug gemcitabine, targeted and killed pancreatic tumor cells. this integrated nanomedicine, showing an increased drug perfusion without any overt side effects, may provide a potential strategy for improvement of the pancreatic cancer therapy.
WOS关键词	STELLATE CELLS ; STROMAL BIOLOGY ; PHASE-III ; MICROENVIRONMENT ; GEMCITABINE ; THERAPY ; NANOPARTICLES ; PIRFENIDONE ; ACTIVATION ; DELIVERY
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000370211400063
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176565
专题	高能物理研究所
通讯作者	Li, Suping; Zhao, Ying; Nie, Guangjun
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Tianjin Med Univ Canc Inst & Hosp, Dept Pancreat Carcinoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin 300060, Peoples R China 4.Jilin Univ, Coll Pharmaceut Sci, Changchun 130021, Peoples R China
推荐引用方式 GB/T 7714	Ji, Tianjiao,Li, Suping,Zhang, Yinlong,et al. An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer[J]. Acs applied materials & interfaces,2016,8(5):3438-3445.
APA	Ji, Tianjiao.,Li, Suping.,Zhang, Yinlong.,Lang, Jiayan.,Ding, Yanping.,...&Nie, Guangjun.(2016).An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer.Acs applied materials & interfaces,8(5),3438-3445.
MLA	Ji, Tianjiao,et al."An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer".Acs applied materials & interfaces 8.5(2016):3438-3445.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。