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	Demonstrating approaches to chemically modify the surface of ag nanoparticles in order to influence their cytotoxicity and biodistribution after single dose acute intravenous administration
	Pang, Chengfang1,2; Brunelli, Andrea2; Zhu, Conghui1; Hristozov, Danail2; Liu, Ying3; Semenzin, Elena2; Wang, Wenwen4; Tao, Wuqun1; Liang, Jingnan5; Marcomini, Antonio2
刊名	Nanotoxicology
	2016-02-07
卷号	10期号:2页码:129-139
关键词	Acute toxicity Pharmacokinetics Protein sorption Surface coating
ISSN号	1743-5390
DOI	10.3109/17435390.2015.1024295
通讯作者	Chen, chunying(chenchy@nanoctr.cn) ; Zhao, bin(binzhao@rcees.ac.cn)
英文摘要	With the advance in material science and the need to diversify market applications, silver nanoparticles (agnps) are modified by different surface coatings. however, how these surface modifications influence the effects of agnps on human health is still largely unknown. we have evaluated the uptake, toxicity and pharmacokinetics of agnps coated with citrate, polyethylene glycol, polyvinyl pyrolidone and branched polyethyleneimine (citrate agnps, peg agnps, pvp agnps and bpei agnps, respectively). our results demonstrated that the toxicity of agnps depends on the intracellular localization that was highly dependent on the surface charge. bpei agnps ( potential=+46.5mv) induced the highest cytotoxicity and dna fragmentation in hepa1c1c7. in addition, it showed the highest damage to the nucleus of liver cells in the exposed mice, which is associated with a high accumulation in liver tissues. the peg agnps ( potential=-16.2mv) showed the cytotoxicity, a long blood circulation, as well as bioaccumulation in spleen (34.33 mu g/g), which suggest better biocompatibility compared to the other chemically modified agnps. moreover, the adsorption ability with bovine serum albumin revealed that the peg surface of agnps has an optimal biological inertia and can effectively resist opsonization or non-specific binding to protein in mice. the overall results indicated that the biodistribution of agnps was significantly dependent on surface chemistry: bpei agnps>citrate agnps=pvp agnps>peg agnps. this toxicological data could be useful in supporting the development of safe agnps for consumer products and drug delivery applications.
WOS关键词	MESENCHYMAL STEM-CELLS ; DEPOSIT-FEEDING SNAIL ; SILVER NANOPARTICLES ; CELLULAR UPTAKE ; PROTEIN CORONA ; OXIDATIVE STRESS ; POTAMOPYRGUS-ANTIPODARUM ; INTRACELLULAR UPTAKE ; TISSUE DISTRIBUTION ; MICRO-CUO
WOS研究方向	Science & Technology - Other Topics ; Toxicology
WOS类目	Nanoscience & Nanotechnology ; Toxicology
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000371822800001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176552
专题	高能物理研究所
通讯作者	Chen, Chunying; Zhao, Bin
作者单位	1.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Ca Foscari Venice, Dept Environm Sci Informat & Stat, Venice, Italy 3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Beihang Univ, Dept Phys, Beijing 100191, Peoples R China 5.Chinese Acad Sci, Inst Microbiol, Core Facil Equipment, Beijing 100085, Peoples R China
推荐引用方式 GB/T 7714	Pang, Chengfang,Brunelli, Andrea,Zhu, Conghui,et al. Demonstrating approaches to chemically modify the surface of ag nanoparticles in order to influence their cytotoxicity and biodistribution after single dose acute intravenous administration[J]. Nanotoxicology,2016,10(2):129-139.
APA	Pang, Chengfang.,Brunelli, Andrea.,Zhu, Conghui.,Hristozov, Danail.,Liu, Ying.,...&Zhao, Bin.(2016).Demonstrating approaches to chemically modify the surface of ag nanoparticles in order to influence their cytotoxicity and biodistribution after single dose acute intravenous administration.Nanotoxicology,10(2),129-139.
MLA	Pang, Chengfang,et al."Demonstrating approaches to chemically modify the surface of ag nanoparticles in order to influence their cytotoxicity and biodistribution after single dose acute intravenous administration".Nanotoxicology 10.2(2016):129-139.

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