| The interplay of size and surface functionality on the cellular uptake of sub-10 nm gold nanoparticles | |
| Jiang, Ying1; Huo, Shuaidong1,2; Mizuhara, Tsukasa1; Das, Riddha1; Lee, Yi-Wei1; Hou, Singyuk1; Moyano, Daniel F.1; Duncan, Bradley1; Liang, Xing-Jie2; Rotello, Vincent M.1 | |
| 刊名 | Acs nano
 |
| 2015-10-01 | |
| 卷号 | 9期号:10页码:9986-9993 |
| 关键词 | Endocytosis pathway Passive fusion Size-dependent Surface charge Sub-10 nm gold nanoparticles |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.5b03521 |
| 通讯作者 | Rotello, vincent m.(rotello@chem.umass.edu) |
| 英文摘要 | Correlation of the surface physicochemical properties of nanoparticles with their interactions with biosystems provides key foundational data for nanomedicine. we report here the systematic synthesis of 2, 4, and 6 nm core gold nanoparticles (aunp) featuring neutral (zwitterionic), anionic, and cationic headgroups. the cellular internalization of these aunps was quantified, providing a parametric evaluation of charge and size effects. contrasting behavior was observed with these systems: with zwitterionic and anionic particles, uptake decreased with increasing aunp size, whereas with cationic particles, uptake increased with increasing particle size. through mechanistic studies of the uptake process, we can attribute these opposing trends to a surface-dictated shift in uptake pathways. zwitterionic nps are primarily internalized through passive diffusion, while the internalization of cationic and anionic nps is dominated by multiple endocytic pathways. our study demonstrates that size and surface charge interact in an interrelated fashion to modulate nanoparticle uptake into cells, providing an engineering tool for designing nanomaterials for specific biological applications. |
| WOS关键词 | CLATHRIN-MEDIATED ENDOCYTOSIS ; DEPENDENT ENDOCYTOSIS ; MAMMALIAN-CELLS ; IN-VIVO ; PENETRATION ; CHEMISTRY ; MECHANISM ; ADSORPTION ; SPHEROIDS ; BEHAVIOR |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000363915300055 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2176457 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Rotello, Vincent M. |
| 作者单位 | 1.Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA 2.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Ying,Huo, Shuaidong,Mizuhara, Tsukasa,et al. The interplay of size and surface functionality on the cellular uptake of sub-10 nm gold nanoparticles[J]. Acs nano,2015,9(10):9986-9993. |
| APA | Jiang, Ying.,Huo, Shuaidong.,Mizuhara, Tsukasa.,Das, Riddha.,Lee, Yi-Wei.,...&Rotello, Vincent M..(2015).The interplay of size and surface functionality on the cellular uptake of sub-10 nm gold nanoparticles.Acs nano,9(10),9986-9993. |
| MLA | Jiang, Ying,et al."The interplay of size and surface functionality on the cellular uptake of sub-10 nm gold nanoparticles".Acs nano 9.10(2015):9986-9993. |
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