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	Mass production of poly(ethylene glycol) monooleate-modified core-shell structured upconversion nanoparticles for bio-imaging and photodynamic therapy
	Zhang, Xingyuan1,2; Guo, Zhao2,3; Zhang, Xiao2; Gong, Linji2,3; Dong, Xinghua3; Fu, Yanyan5; Wang, Qing1,4; Gu, Zhanjun2,3
刊名	Scientific reports
	2019-03-26
卷号	9页码:10
ISSN号	2045-2322
DOI	10.1038/s41598-019-41482-w
通讯作者	Zhang, xingyuan(zhangx89@ihep.ac.cn) ; Fu, yanyan(fuyy@mail.sim.ac.cn) ; Wang, qing(profqwang@163.com)
英文摘要	Developing robust and high-efficient synthesis approaches has significant importance for the expanded applications of upconversion nanoparticles (ucnps). here, we report a high-throughput synthesis strategy to fabricate water-dispersible core-shell structured ucnps. firstly, we successfully obtain more than 10 grams core ucnps with high quality from one-pot reaction using liquid rare-earth precursors. afterwards, different core-shell structured ucnps are fabricated by successive layer-by-layer strategy to get enhanced fluorescence property. finally, the hydrophobic ucnps are modified with poly(ethylene glycol) monooleate (peg-oa) though a novel physical grinding method. on the basis of mass-production, we use the as-prepared peg-ucnps to construct an 808-nm stimuli photodynamic therapy agent, and apply them in cancer therapy and bio-imaging.
资助项目	National Basic Research Programs of China[2016YFA0201600] ; National Basic Research Programs of China[2018YFA0107302] ; National Natural Science Foundation of China[51772292] ; National Natural Science Foundation of China[31571015] ; National Natural Science Foundation of China[11621505] ; National Natural Science Foundation of China[11435002] ; National Natural Science Foundation of China[21320102003] ; Youth Innovation Promotion Association CAS[2013007] ; Youth Innovation Promotion Association CAS[2015190] ; Taishan Scholarship Project of Shandong Province, China[TSHW20130956] ; Shandong Provincial Natural Science Foundation, China[ZR2017MA013]
WOS关键词	NEAR-INFRARED LIGHT ; NAYF4 NANOCRYSTALS ; NITRIC-OXIDE ; GROWTH ; PHASE ; IONS ; NANOPHOSPHORS ; DECOMPOSITION ; LUMINESCENCE ; LANTHANIDES
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000462298600099
资助机构	National Basic Research Programs of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Taishan Scholarship Project of Shandong Province, China ; Shandong Provincial Natural Science Foundation, China
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2160645
专题	高能物理研究所
通讯作者	Zhang, Xingyuan; Fu, Yanyan; Wang, Qing
作者单位	1.Shandong Univ Sci & Technol, Coll Civil Engn & Architecture, Inst Nano Engn, Qingdao 266590, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shandong Univ Sci & Technol, Sch Mat Sci & Engn, Qingdao 266590, Peoples R China 5.Chinese Acad Sci, State Key Lab Transducer Technol, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xingyuan,Guo, Zhao,Zhang, Xiao,et al. Mass production of poly(ethylene glycol) monooleate-modified core-shell structured upconversion nanoparticles for bio-imaging and photodynamic therapy[J]. Scientific reports,2019,9:10.
APA	Zhang, Xingyuan.,Guo, Zhao.,Zhang, Xiao.,Gong, Linji.,Dong, Xinghua.,...&Gu, Zhanjun.(2019).Mass production of poly(ethylene glycol) monooleate-modified core-shell structured upconversion nanoparticles for bio-imaging and photodynamic therapy.Scientific reports,9,10.
MLA	Zhang, Xingyuan,et al."Mass production of poly(ethylene glycol) monooleate-modified core-shell structured upconversion nanoparticles for bio-imaging and photodynamic therapy".Scientific reports 9(2019):10.

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