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	Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2h-phase nano-mos2
	Mei, Linqiang1,2,3; Zhang, Xiao2,3; Yin, Wenyan2,3; Dong, Xinghua2,3; Guo, Zhao2,3; Fu, Wenhui2,3; Su, Chunjian1; Gu, Zhanjun2,3; Zhao, Yuliang2,3
刊名	Nanoscale
	2019-03-21
卷号	11期号:11页码:4767-4780
ISSN号	2040-3364
DOI	10.1039/c8nr10319d
通讯作者	Yin, wenyan(yinwy@ihep.ac.cn) ; Su, chunjian(suchunjian2008@163.com) ; Gu, zhanjun(zjgu@ihep.ac.cn)
英文摘要	Nano-mos2 has been extensively investigated in materials science and biomedicine. however, the effects of different methods of exposure on their translocation, biosafety, and biotransformation-related degradability remain unclear. in this study, we combined the advantages of synchrotron radiation (sr) x-ray absorption near-edge structure (xanes) and high-resolution single-cell sr transmission x-ray microscopy (sr-txm) with traditional analytical techniques to investigate translocation, precise degraded species/ratio, and correlation between the degradation and toxicity levels of polyvinylpyrrolidone-modified 2h-phase mos2 nanosheets (mos2-pvp nss). these nss demonstrated different biodegradability levels in biomicroenvironments with h2o2, catalase, and human myeloperoxidase (hmpo) (h2o2 < catalase < hmpo). the effects of nss and their biodegraded byproducts on cell viability and 3d translocation at the single-cell level were also assessed. toxicity and translocation in mice via intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i.g.) administration routes guided by fluorescence (fl) imaging were investigated within the tested dosage. after i.g. administration, nss accumulated in the gastrointestinal organs and were excreted from feces within 48 h. after i.v. injection, nss showed noticeable clearance due to their decreased accumulation in the liver and spleen within 30 days when compared with that in the i.p. group, which exhibited slight accumulation in the spleen. this work paves the way for understanding the biological behaviors of nano-mos2 using sr techniques that provide more opportunities for future applications.
资助项目	National Basic Research Programs of China[2016YFA0201600] ; National Basic Research Programs of China[2015CB932104] ; National Natural Science Foundation of China[51772293] ; National Natural Science Foundation of China[51822207] ; National Natural Science Foundation of China[51772292] ; National Natural Science Foundation of China[11621505] ; National Natural Science Foundation of China[31571015] ; National Natural Science Foundation of China[21320102003] ; Beijing Natural Science Foundation[2162046] ; Shandong Provincial Natural Science Foundation of China[ZR2018MEE022]
WOS关键词	TRANSITION-METAL DICHALCOGENIDES ; MOS2 NANOSHEETS ; MOLYBDENUM-DISULFIDE ; DRUG-DELIVERY ; NANOPARTICLES ; BIODISTRIBUTION ; GRAPHENE ; NANOMATERIALS ; CYTOTOXICITY ; SAFE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000462669600011
资助机构	National Basic Research Programs of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Shandong Provincial Natural Science Foundation of China
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2160593
专题	高能物理研究所
通讯作者	Yin, Wenyan; Su, Chunjian; Gu, Zhanjun
作者单位	1.Shandong Univ Sci & Technol, Coll Mech & Elect Engn, Qingdao 266590, Shandong, Peoples R China 2.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Mei, Linqiang,Zhang, Xiao,Yin, Wenyan,et al. Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2h-phase nano-mos2[J]. Nanoscale,2019,11(11):4767-4780.
APA	Mei, Linqiang.,Zhang, Xiao.,Yin, Wenyan.,Dong, Xinghua.,Guo, Zhao.,...&Zhao, Yuliang.(2019).Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2h-phase nano-mos2.Nanoscale,11(11),4767-4780.
MLA	Mei, Linqiang,et al."Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2h-phase nano-mos2".Nanoscale 11.11(2019):4767-4780.

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