Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward

doi:10.7554/eLife.25423

CORC > 武汉植物园 > 中国科学院武汉植物园

	Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward
	Zhang, Xueyi 3; He, Xiaobin 1; Li, Juan 1; Zhou, Zheng 4,5; Xu, Xiaoran 3; Luo, Rui 3; Lv, Guanghui 2; Li, Haohong 2; Cao, Pei 1; Wang, Liping
刊名	ELIFE
	2017-12-16
卷号	6 页码:24
ISSN号	2050-084X
DOI	10.7554/eLife.25423
英文摘要	Odor-preferences are usually influenced by life experiences. However, the neural circuit mechanisms remain unclear. The medial olfactory tubercle (mOT) is involved in both reward and olfaction, whereas the ventral tegmental area (VTA) dopaminergic (DAergic) neurons are considered to be engaged in reward and motivation. Here, we found that the VTA (DAergic)-mOT pathway could be activated by different types of naturalistic rewards as well as odors in DAT-cre mice. Optogenetic activation of the VTA-mOT DAergic fibers was able to elicit preferences for space, location and neutral odor, while pharmacological blockade of the dopamine receptors in the mOT fully prevented the odor-preference formation. Furthermore, inactivation of the mOT-projecting VTA DAergic neurons eliminated the previously formed odor-preference and strongly affected the Go-no go learning efficiency. In summary, our results revealed that the VTA (DAergic)-mOT pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference in mice.
资助项目	National Natural Science Foundation of China[31400945] ; National Natural Science Foundation of China[31400946] ; National Natural Science Foundation of China[31400977] ; National Natural Science Foundation of China[81661148053] ; National Natural Science Foundation of China[91632303] ; National Natural Science Foundation of China[31771156] ; Ministry of Science and Technology of the People's Republic of China[2015CB755600] ; Chinese Academy of Sciences[XDB02050005]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
出版者	ELIFE SCIENCES PUBLICATIONS LTD
WOS记录号	WOS:000423033300001
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/4469]
专题	中国科学院武汉植物园
通讯作者	Xu, Fuqiang
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Ctr Brain Sci, Key Lab Magnet Resonance Biol Syst, Wuhan, Hubei, Peoples R China 2.Wuhan Natl Lab Optoelect, Wuhan, Hubei, Peoples R China 3.Wuhan Univ, Coll Life Sci, Wuhan, Hubei, Peoples R China 4.Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Ctr Excellence Brain Sci, Shenzhen Key Lab Neuropsychiat Modulat, Shenzhen, Peoples R China 5.Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Ctr Excellence Brain Sci, Collaborat Innovat Ctr Brain Sci, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xueyi,He, Xiaobin,Li, Juan,et al. Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward[J]. ELIFE,2017,6:24.
APA	Zhang, Xueyi.,He, Xiaobin.,Li, Juan.,Zhou, Zheng.,Xu, Xiaoran.,...&Zhang, Hongruo.(2017).Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward.ELIFE,6,24.
MLA	Zhang, Xueyi,et al."Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward".ELIFE 6(2017):24.