Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum) | |
Zhou, Pan-Pan1; Yang JL(杨军丽); Shi YP(师彦平)2; Meng XH(孟宪华)2; Yang JL(杨军丽)2; Wang J(王君)2,3 | |
刊名 | Journal of Agricultural and Food Chemistry |
2017 | |
卷号 | 65期号:29页码:5926-5934 |
关键词 | Jiaogulan Gynostemma Pentaphyllum New Gypenosides Ptp1b Inhibitory Activity Cytotoxicity |
ISSN号 | 0021-8561 |
DOI | 10.1021/acs.jafc.7b01477 |
英文摘要 | Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. In this study, six new gypenosides (1–6) were isolated from the aerial parts of G. pentaphyllum. Their molecular structures were elucidated through spectroscopic analysis and acid hydrolysis. Gypenosides 1 and 2 represented the first example of a dammar-21-O- glucopyranoside without any unsaturated functional group and a dammar-3-O-glucopyranosyl-25-O-glucopyranoside without any cyclization in the side chain, respectively. In addition, gypenosides 5 and 6 exhibited the first example of a 24-hydroperoxy-19-oxo-dammarane triterpenoid and 19-oxo-dammar-21-O-glucopyranoside with a saturated side chain, respectively. Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC50 value of 8.2 ± 0.9 μM, and moderate cytotoxicity against human breast cancer cells MCF7, MCF7/ADR, and MDA-MB-231, with IC50 values ranging from 10.5 ± 1.4 to 14.2 ± 2.6 μM. The outcome of the study provided crucial information regarding the structural diversity and health benefits of gypenosides. |
学科主题 | 分析化学与药物化学 |
资助项目 | 药物化学成分研究组 |
语种 | 英语 |
WOS记录号 | WOS:000406649400009 |
资助机构 | the National Natural Science Foundation of China (81673325);the CAS Pioneer Hundred Talents Program;the Top Priority Program of “One-Three-Five” Strategic Planning of the Lanzhou Institute of Chemical Physics of CAS |
内容类型 | 期刊论文 |
源URL | [http://ir.licp.ac.cn/handle/362003/22440] |
专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
通讯作者 | Yang JL(杨军丽) |
作者单位 | 1.College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, People’s Republic of China 2.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People’s Republic of China 3.University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China |
推荐引用方式 GB/T 7714 | Zhou, Pan-Pan,Yang JL,Shi YP,et al. Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)[J]. Journal of Agricultural and Food Chemistry,2017,65(29):5926-5934. |
APA | Zhou, Pan-Pan,杨军丽,Shi YP,Meng XH,Yang JL,&Wang J.(2017).Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum).Journal of Agricultural and Food Chemistry,65(29),5926-5934. |
MLA | Zhou, Pan-Pan,et al."Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)".Journal of Agricultural and Food Chemistry 65.29(2017):5926-5934. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论