Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures

doi:10.1007/s12274-017-1592-5

	Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures
	Tao, Guiju 1,2; Bai, Zhengyuan 1; Chen, Yu 3; Yao, Heliang 4; Wu, Meiying 3,7; Huang, Ping 3; Yu, Luodan 3; Zhang, Jiamin 5; Dai, Chen 6; Zhang, Long 1
刊名	Nano Research
	2017
卷号	10 期号:11 页码:3790-3810
ISSN号	19980124
DOI	10.1007/s12274-017-1592-5
英文摘要	Precise control over the morphology, nanostructure, composition, and particle size of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles (MONs) still remains a major challenge, which severely restricts their broad applications. In this work, an efficient bridged organic group-determined growth strategy has been proposed for the facile synthesis of highly dispersed and uniform MONs with multifarious Janus morphologies, nanostructures, organic–inorganic hybrid compositions, and particle sizes, which can be easily controlled simply by varying the bridged organic groups and the concentration of bis-silylated organosilica precursors used in the synthesis. In addition, the formation mechanism of Janus MONs determined by the bridged organic group has been discussed. Based on the specific structures, compositions, and asymmetric morphologies, all the synthesized Janus MONs with hollow structures (JHMONs) demonstrate excellent performances in nanomedicine as desirable drug carriers with high drug-loading efficiencies/capacities, pH-responsive drug releasing, and enhanced therapeutic efficiencies, as attractive contrast-enhanced contrast agents for ultrasound imaging, and as excellent bilirubin adsorbents with noticeably high adsorption capacities and high blood compatibilities. The developed versatile synthetic strategy and the obtained JHMONs are extremely important in the development and applications of MONs, particularly in the areas of nanoscience and nanotechnology. [Figure not available: see fulltext.]. © 2017, Tsinghua University Press and Springer-Verlag GmbH Germany.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25863]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai; 201800, China; 2.Sinopec Shanghai Research Institute of Petrochemical Technology, Shanghai; 201208, China; 3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 4.Analysis and Testing Center for Inorganic Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 5.Shanghai (Red Cross) Blood Center, Shanghai Institute of Blood Transfusion, Shanghai; 200051, China; 6.Department of Ultrasound, the East Hospital Affiliated to Tongji University, Shanghai; 200120, China; 7.Paui C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen; 518055, China
推荐引用方式 GB/T 7714	Tao, Guiju,Bai, Zhengyuan,Chen, Yu,et al. Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures[J]. Nano Research,2017,10(11):3790-3810.
APA	Tao, Guiju.,Bai, Zhengyuan.,Chen, Yu.,Yao, Heliang.,Wu, Meiying.,...&Zhang, Long.(2017).Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures.Nano Research,10(11),3790-3810.
MLA	Tao, Guiju,et al."Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures".Nano Research 10.11(2017):3790-3810.