Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles

doi:10.1021/acsami.6b15448

	Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles
	Cao, Huiliang 1; Zhang, Wenjie 2; Meng, Fanhao 1; Guo, Jinshu 1; Wang, Donghui 1; Qian, Shi 1; Jiang, Xinquan 2; Liu, Xuanyong 1; Chu, Paul K.3
刊名	ACS Applied Materials and Interfaces
	2017
卷号	9 期号:6 页码:5149-5157
ISSN号	19448244
DOI	10.1021/acsami.6b15448
英文摘要	Silver nanoparticles (Ag NPs) were widely explored for antimicrobial applications, whereas the translation into drugs and implantable antibacterial devices provoked serious concerns about their potential cytotoxicity. Herein, Ag NPs with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin α5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium. It was demonstrated that the titanium-supported Ag NPs played an important role in motivating integrin α5 through triggering the galvanic hydrogen evolution reactions, which was found in positive correlation with the distribution density of the immobilized Ag NPs. Since cellular uptake is a key factor determining the cytotoxic performance of Ag NPs, the extracellular effects of immobilized Ag NPs on promoting osteogenesis provided new insights into the safe application of nanomaterials, and into designing and developing renewed antibacterial devices with selective toxicity. © 2017 American Chemical Society.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25893]
专题	中国科学院上海硅酸盐研究所
作者单位	1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.Department of Prosthodontics, School of Medicine, Ninth People's Hospital Affiliated, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai; 200011, China; 3.Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong
推荐引用方式 GB/T 7714	Cao, Huiliang,Zhang, Wenjie,Meng, Fanhao,et al. Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles[J]. ACS Applied Materials and Interfaces,2017,9(6):5149-5157.
APA	Cao, Huiliang.,Zhang, Wenjie.,Meng, Fanhao.,Guo, Jinshu.,Wang, Donghui.,...&Chu, Paul K..(2017).Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles.ACS Applied Materials and Interfaces,9(6),5149-5157.
MLA	Cao, Huiliang,et al."Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles".ACS Applied Materials and Interfaces 9.6(2017):5149-5157.