Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells

doi:10.1016/j.carbon.2017.09.064

	Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells
	Qiu, Jiajun 1,3; Guo, Jingshu 1,3; Geng, Hao 1,3; Qian, Wenhao 2; Liu, Xuanyong 1
刊名	Carbon
	2017
卷号	125 页码:227-235
ISSN号	00086223
DOI	10.1016/j.carbon.2017.09.064
英文摘要	Currently, graphene and its derivatives, used for surface modification of orthopedic and dental implants, are mainly in the form of two-dimensional planar structure. There is little information of three dimensional porous graphene nanosheets used as coating materials of titanium and its alloys. In the present study, three dimensional porous graphene nanosheets were first synthesized on the pure titanium surface. The physicochemical properties and osteogenic activity of the three dimensional porous graphene nanosheets-modified titanium (rGO@Ti) were systematically investigated. The results suggested that rGO@Ti showed super hydrophilicity, rough surface and excellent biocompatibility, and could enhance alkaline phosphatase (ALP) activity, extracellular matrix (ECM) mineralization and collagen secretion of rat bone mesenchymal stem cells (rBMSCs). Meanwhile, the expressions of osteogenesis related genes containing ALP, bone morphogenic protein-2 (BMP-2), osteocalcin (OCN), and osteopontin (OPN) on rGO@Ti were improved. The osteogenic differentiation of rBMSCs on rGO@Ti may be ascribed to both its superior protein adsorption ability and physical stimulation induced by the unique structure of three dimensional porous graphene nanosheets. © 2017 Elsevier Ltd
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25910]
专题	中国科学院上海硅酸盐研究所
作者单位	1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.Shanghai Xuhui District Dental Center, Shanghai; 200032, China; 3.University of Chinese Academy of Sciences, Beijing; 100049, China
推荐引用方式 GB/T 7714	Qiu, Jiajun,Guo, Jingshu,Geng, Hao,et al. Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells[J]. Carbon,2017,125:227-235.
APA	Qiu, Jiajun,Guo, Jingshu,Geng, Hao,Qian, Wenhao,&Liu, Xuanyong.(2017).Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells.Carbon,125,227-235.
MLA	Qiu, Jiajun,et al."Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells".Carbon 125(2017):227-235.