Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain | |
Biliang Zhang1,4; Jia-hai Lu5; Yi-fei Wang7; Huan-ying Zheng3; Sheng Xiong7; Chuan-hai Zhang2,6,7; Mei-ying Zhang7; Xin-ge Yan3; Zhuo-yue Wan3; Xin-jian Liu7 | |
刊名 | Vaccine |
2005-05-02 | |
卷号 | 23期号:24页码:3196-3201 |
关键词 | Sars Coronavirus (Sars-cov) Inactivated Vaccine Immunogenicity Balb/c Mouse |
DOI | 10.1016/j.vaccine.2004.11.073 |
英文摘要 | The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(OH)3 adjuvant and CpG adjuvant). Titers of specific IgG antibodies in three test groups all peaked in the sixth week after first vaccination, but significant differences existed in the kinetics of specific IgG antibody levels. The strong neutralizing capacity exhibited in micro-cytopathic effect neutralization tests indicated the specific antibodies are protective. Western blot assay further demonstrated the specificity of the induced serum antibodies. |
URL标识 | 查看原文 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.foo.ac.cn/handle/2SETSVCV/881] |
专题 | 中国科学院广州生物医药与健康研究院 |
作者单位 | 1.Program in Molecular Medicine, University of Massachusetts Medical School 2.South China Institute of Botany, Graduate School of the Chinese Academy of Sciences 3.Center for Diseases Control and Prevention of Guangdong Province 4.Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences 5.School of Public Health, Sun Yat-sen University 6.West Anhui University 7.Biomedicine Research and Development Center, Jinan University |
推荐引用方式 GB/T 7714 | Biliang Zhang,Jia-hai Lu,Yi-fei Wang,et al. Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain[J]. Vaccine,2005,23(24):3196-3201. |
APA | Biliang Zhang.,Jia-hai Lu.,Yi-fei Wang.,Huan-ying Zheng.,Sheng Xiong.,...&Zhiyong Cui.(2005).Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain.Vaccine,23(24),3196-3201. |
MLA | Biliang Zhang,et al."Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain".Vaccine 23.24(2005):3196-3201. |
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