Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy

doi:10.1021/acs.analchem.6b04548

	Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy
	Hu, Ping 1,2; Wang, Rui 1; Zhou, Lei 1; Chen, Lei 1; Wu, Qingsheng 3; Han, Ming-Yong 4; El-Toni, Ahmed Mohamed 5; Zhao, Dongyuan 1; Zhang, Fan 1
刊名	Analytical Chemistry
	2017
卷号	89 期号:6 页码:3492-3500
ISSN号	00032700
DOI	10.1021/acs.analchem.6b04548
英文摘要	As a light-activated noninvasive cancer treatment paradigm, photodynamic therapy (PDT) has attracted extensive attention because of its high treatment efficacy and low side effects. Especially, spatiotemporal control of singlet oxygen (1O2) release is highly desirable for realizing on-demand PDT, which, however, still remains a huge challenge. To address this issue, a novel switchable near-infrared (NIR)-responsive upconversion nanoprobe has been designed and successfully applied for controlled PDT that can be optically activated by tumor-associated disruption of labile Zn2+(denoted as Zn2+hereafter) homeostasis stimuli. Upon NIR irradiation, this theranostic probe can not only quantitatively detect the intracellular endogenous Zn2+in situ but also selectively generate a great deal of cytotoxic reactive oxygen species (ROS) for efficiently killing breast cancer cells under the activation of excessive endogenous Zn2+, so as to maximally avoid adverse damage to normal cells. This study aims to propose a new tumor-specific PDT paradigm and, more importantly, provide a new avenue of thought for efficient cancer theranostics based on our designed highly sensitive upconversion nanoprobes. (Figure Presented). © 2017 American Chemical Society.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25385]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai; 200433, China; 2.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 3.Department of Chemistry, Tongji University, Shanghai; 200092, China; 4.Institute of Materials Research and Engineering, 2 Fusionopolis Way, Singapore; 138634, Singapore; 5.King Abdullah Institute for Nanotechnology, King Saud University, Riyadh; 11451, Saudi Arabia
推荐引用方式 GB/T 7714	Hu, Ping,Wang, Rui,Zhou, Lei,et al. Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy[J]. Analytical Chemistry,2017,89(6):3492-3500.
APA	Hu, Ping.,Wang, Rui.,Zhou, Lei.,Chen, Lei.,Wu, Qingsheng.,...&Zhang, Fan.(2017).Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy.Analytical Chemistry,89(6),3492-3500.
MLA	Hu, Ping,et al."Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy".Analytical Chemistry 89.6(2017):3492-3500.