Synergistic effects of titania nanotubes and silicon to enhance the osteogenic activity

doi:10.1016/j.colsurfb.2018.07.052

	Synergistic effects of titania nanotubes and silicon to enhance the osteogenic activity
	Wang, Tao 1,2; Qian, Shi 3; Zha, Guo-Chun 4; Zhao, Xi-Jiang 1; Ding, Lei 2; Sun, Jun-Ying 5; Li, Bin 5; Liu, Xuan-Yong 3
刊名	Colloids and Surfaces B: Biointerfaces
	2018
卷号	171 页码:419-426
ISSN号	09277765
DOI	10.1016/j.colsurfb.2018.07.052
英文摘要	In this study, titania nanotubes (TNTs) incorporating silicon (Si) were formed on Ti disks using anodization and electron beam evaporation (EBE) technology to improve the osteogenic activity. The amount of Si was exquisitely adjusted by controlling the duration of EBE to optimize the biofunctionality. As the Si was incorporated, the samples exhibited hydrophilic surfaces. Long lasting and controllable Si release was observed from the EBE-modified samples without cytotoxicity. Moreover, initial cell adhesion, spreading, proliferation and osteogenic differentiation of MC3T3-E1 cells were evaluated. The results showed a notable enhancement of spreading, osteogenesis and differentiation of cells on silicon-coated TNTs (Si-TNTs). In particular, samples with highest amount of silicon (∼5.93% Si) displayed greatest augmentation of ALP activity, osteogenic-related gene expression and mineralization compared to the others in the present study. It was indicated that the modification with TNTs and appropriated Si content resulted in enhanced osteoblastic spreading, proliferation and differentiation, and therefore has the potential for future applications in the field of orthopedics. © 2018
出版者	Elsevier B.V.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25259]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Department of Orthopedics, Affiliated Hospital of Jiangnan University, Wuxi; Jiangsu; 214062, China; 2.School of Medicine, Jiangnan University, Wuxi; Jiangsu; 214122, China; 3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 4.Department of Orthopedics, the Affiliated Hospital of Xuzhou Medical University, Xuzhou; Jiangsu; 221002, China; 5.Department of Orthopedics, the First Affiliated Hospital, Orthopaedic Institute, Soochow University, Suzhou; Jiangsu; 215006, China
推荐引用方式 GB/T 7714	Wang, Tao,Qian, Shi,Zha, Guo-Chun,et al. Synergistic effects of titania nanotubes and silicon to enhance the osteogenic activity[J]. Colloids and Surfaces B: Biointerfaces,2018,171:419-426.
APA	Wang, Tao.,Qian, Shi.,Zha, Guo-Chun.,Zhao, Xi-Jiang.,Ding, Lei.,...&Liu, Xuan-Yong.(2018).Synergistic effects of titania nanotubes and silicon to enhance the osteogenic activity.Colloids and Surfaces B: Biointerfaces,171,419-426.
MLA	Wang, Tao,et al."Synergistic effects of titania nanotubes and silicon to enhance the osteogenic activity".Colloids and Surfaces B: Biointerfaces 171(2018):419-426.