Degradability and biocompatibility of magnesium-MAO: The consistency and contradiction between in-vitro and in-vivo outcomes

doi:10.1016/j.arabjc.2018.07.010

	Degradability and biocompatibility of magnesium-MAO: The consistency and contradiction between in-vitro and in-vivo outcomes
	Xu, Haitao 1; Hu, Tu 2; Wang, Manle 3; Zheng, Yuxin 1; Qin, Hui 2; Cao, Huiliang 3; An, Zhiquan 2
刊名	Arabian Journal of Chemistry
	2018
ISSN号	18785352
DOI	10.1016/j.arabjc.2018.07.010
英文摘要	Magnesium-based metals are promising for biomedical use for its biodegradation characteristic. However, its rapid degradation in physiological environment impedes its application. Oxides coating is a widely-used form of surface modification to improve the corrosion resistance of biomaterials. In this study, we systematically compared two oxides coatings, steam oxidation (SO) and micro-arc oxidation (MAO), in controlling degradation and improving the biocompatibility of pure magnesium in vitro and in vivo. The addition of both coatings was found to reduce the degradation rate of magnesium in vitro at the early stage, but the corrosion behavior became severe with longer immersion time in all the groups. Unfortunately, all the coated and uncoated materials were found undermining the adhesion and proliferation of MC3T3-E1 cells in vitro, even at the first day of culture. In terms of in-vivo circumstance, the Mg-MAO group showed satisfying biocompatibility compared with pure Mg and Mg-SO, as is evidenced by radiographic results and histological analysis. Little corrosion was found, and more newly formed bone was observed in the animal model. These data suggest that the characteristic of in-vivo circumstance have considerable impacts on the degradation and bone integration process. © 2018 King Saud University
出版者	Elsevier B.V.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25151]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Department of Orthopedics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; 2.Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China; 3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China
推荐引用方式 GB/T 7714	Xu, Haitao,Hu, Tu,Wang, Manle,et al. Degradability and biocompatibility of magnesium-MAO: The consistency and contradiction between in-vitro and in-vivo outcomes[J]. Arabian Journal of Chemistry,2018.
APA	Xu, Haitao.,Hu, Tu.,Wang, Manle.,Zheng, Yuxin.,Qin, Hui.,...&An, Zhiquan.(2018).Degradability and biocompatibility of magnesium-MAO: The consistency and contradiction between in-vitro and in-vivo outcomes.Arabian Journal of Chemistry.
MLA	Xu, Haitao,et al."Degradability and biocompatibility of magnesium-MAO: The consistency and contradiction between in-vitro and in-vivo outcomes".Arabian Journal of Chemistry (2018).