Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing

doi:10.1016/j.colsurfb.2018.02.001

	Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing
	Guo, Jingshu 1; Ning, Congqin ; Liu, Xuanyong
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2018
卷号	164 页码:388
关键词	Calcium phosphate silicate coating PLGA Surface modification Tendon-to-bone healing Electron beam evaporation
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2018.02.001
英文摘要	Due to the dissimilar features between the tendon and bone, tendon to bone healing is the most challenging problems in sports medicine. In the present work, a novel bioactive calcium phosphate silicate ceramic (CPS) was coated on the surface of PLGA films using electron beam evaporation (EBE) technique to prepare a tailorable composite film with layered chemical composition similar to tendon-bone interface. The physicochemical behaviors of the CPS-PLGA composite films were characterized and the cytocompatibility were also investigated. It was found that the CPS-modified samples exhibited a significantly improved hydrophilicity and a more negative zeta potential. Cell culture results showed that the CPS-modified samples were beneficial to the attachment and proliferation of rBMSCs and NIH3T3 cells. CPS-modified samples also showed an improved osteogenic activity. The results suggested that CPS-modified PLGA films have great potentials for tendon-bone healing. (C) 2018 Elsevier B.V. All rights reserved.
学科主题	Biophysics ; Chemistry, Physical ; Materials Science, bioMaterials
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000429762100045
资助机构	The authors are grateful to the financial supports from National Science Foundation for Distinguished Young Scholars of China (51525207) and National Natural Science foundation of China (51672304). ; The authors are grateful to the financial supports from National Science Foundation for Distinguished Young Scholars of China (51525207) and National Natural Science foundation of China (51672304).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25039]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Guo, Jingshu,Ning, Congqin,Liu, Xuanyong. Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018,164:388, 395.
APA	Guo, Jingshu,Ning, Congqin,&Liu, Xuanyong.(2018).Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing.COLLOIDS AND SURFACES B-BIOINTERFACES,164,388.
MLA	Guo, Jingshu,et al."Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing".COLLOIDS AND SURFACES B-BIOINTERFACES 164(2018):388.