Tumor Microenvironment-Enabled Nanotherapy

doi:10.1002/adhm.201701156

	Tumor Microenvironment-Enabled Nanotherapy
	Wang, Liying 1,2; Huo, Minfeng 1; Chen, Yu ; Shi, Jianlin
刊名	ADVANCED HEALTHCARE MATERIALS
	2018
卷号	7 期号:8
关键词	cancer treatment nanomedicine nanotherapy tumor microenvironment
ISSN号	2192-2640
DOI	10.1002/adhm.201701156
英文摘要	Cancer is now one of the world's leading threats to human health. With the development of oncology in both biology and biomedicine, it has been demon-strated that abnormal physiochemical conditions and dysregulated biosynthetic intermediates in tumor microenvironment (TME) play a pivotal role in enabling tumor cells to defend or evade the damage by traditional clinical tumor therapeutics including surgery, chemotherapy, radiotherapy, etc. The fast advances of TME-enabled theranostic nanomedicine have offered promising perspectives, strategies, and approaches for combating cancer based on the novel concept of TME-enabled nanotherapy. In this comprehensive review, the origins of TME (e.g., enhanced permeability and retention effect, overexpressed biosynthetic intermediates, mild acidic nature, redox potentials, hypoxia) are initially introduced and discussed, followed by detailed discussion and overview on the state-of-the-art progresses in TME-enabled antitumor nanotherapies (e.g., chemo/chemodynamic therapy, photodynamic therapy, radiotherapy). Finally, the obstacles and challenges of future development on TME-enabled nanotherapies for further clinical translation are outlooked.
学科主题	Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, bioMaterials
出版者	WILEY
WOS记录号	WOS:000430804800005
资助机构	L.W. and M.H. contributed equally to this work. The authors greatly acknowledge the financial support from National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51722211 and 51672303), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Natural Science Foundation of Shanghai (Grant No. 13ZR1463500), and Youth Innovation Promotion Association (Grant No. 2013169). ; L.W. and M.H. contributed equally to this work. The authors greatly acknowledge the financial support from National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51722211 and 51672303), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Natural Science Foundation of Shanghai (Grant No. 13ZR1463500), and Youth Innovation Promotion Association (Grant No. 2013169).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24974]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Wang, Liying,Huo, Minfeng,Chen, Yu,et al. Tumor Microenvironment-Enabled Nanotherapy[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(8).
APA	Wang, Liying,Huo, Minfeng,Chen, Yu,&Shi, Jianlin.(2018).Tumor Microenvironment-Enabled Nanotherapy.ADVANCED HEALTHCARE MATERIALS,7(8).
MLA	Wang, Liying,et al."Tumor Microenvironment-Enabled Nanotherapy".ADVANCED HEALTHCARE MATERIALS 7.8(2018).