2D Ultrathin MXene-Based Drug-Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer

doi:10.1002/adhm.201701394

	2D Ultrathin MXene-Based Drug-Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer
	Han, Xiaoxia ; Huang, Ju ; Lin, Han 1; Wang, Zhigang ; Li, Pan ; Chen, Yu 1
刊名	ADVANCED HEALTHCARE MATERIALS
	2018
卷号	7 期号:9
关键词	cancer drug delivery MXene nanomedicine photothermal therapy synergistic therapy
ISSN号	2192-2640
DOI	10.1002/adhm.201701394
英文摘要	Two-dimensional (2D) MXenes, as a new 2D functional material nanosystem, have been extensively explored for broad applications. However, their specific performance and applications in theranostic nanomedicine have still rarely been explored. This work reports on the drug-delivery performance and synergistic therapeutic efficiency of Ti3C2 MXenes for highly efficient tumor eradication. These Ti3C2 MXenes not only possess high drug-loading capability of as high as 211.8%, but also exhibit both pH-responsive and near infrared laser-triggered on-demand drug release. Especially, based on the high photothermal-conversion capability of Ti3C2 MXenes, they have been further explored for efficient tumor eradication by synergistic photothermal ablation and chemotherapy, which has been systematically demonstrated both in vitro and in vivo. These Ti3C2 MXenes have also been demonstrated as the desirable contrast agents for photoacoustic imaging, showing the potential for diagnostic-imaging guidance and monitoring during therapy. The high in vivo histocompatibility of Ti3C2 and their easy excretion out of the body have been evaluated and demonstrated, showing the potential high biosafety for further clinical translation. This work paves a new way for broadening biomedical applications of MXenes in nanomedicine where they can exert the high performance and functionality for synergistic therapy, especially on combating cancer.
学科主题	Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, bioMaterials
出版者	WILEY
WOS记录号	WOS:000431960000013
资助机构	The authors gratefully acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant Nos. 51722211, 51672303, and 81371578), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). ; The authors gratefully acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant Nos. 51722211, 51672303, and 81371578), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24927]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chongqing Med Univ, Inst Ultrasound Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China 2.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Han, Xiaoxia,Huang, Ju,Lin, Han,et al. 2D Ultrathin MXene-Based Drug-Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(9).
APA	Han, Xiaoxia,Huang, Ju,Lin, Han,Wang, Zhigang,Li, Pan,&Chen, Yu.(2018).2D Ultrathin MXene-Based Drug-Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer.ADVANCED HEALTHCARE MATERIALS,7(9).
MLA	Han, Xiaoxia,et al."2D Ultrathin MXene-Based Drug-Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer".ADVANCED HEALTHCARE MATERIALS 7.9(2018).