Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles

doi:10.1021/acsnano.8b01994

	Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles
	Bao, Qunqun 1,2; Hu, Ping ; Xu, Yingying 2; Cheng, Tiansheng 2; Wei, Chenyang ; Pan, Limin ; Shi, Jianlin
刊名	ACS NANO
	2018
卷号	12 期号:7 页码:6794
关键词	stroke blood-brain barrier ceria nanoparticles edaravone reactive oxygen species
ISSN号	1936-0851
DOI	10.1021/acsnano.8b01994
英文摘要	Cerebral vasculature and neuronal networks will be largely destroyed due to the oxidative damage by overproduced reactive oxygen species (ROS) during a stroke, accompanied by the symptoms of ischemic injury and blood-brain barrier (BBB) disruption. Ceria nanoparticles, acting as an effective and recyclable ROS scavenger, have been shown to be highly effective in neuroprotection. However, the brain access of nanoparticles can only be achieved by targeting the damaged area of BBB, leading to the disrupted BBB being unprotected and to turbulence of the microenvironment in the brain. Nevertheless, the integrity of the BBB will cause very limited accumulation of therapeutic nanoparticles in brain lesions. This dilemma is a great challenge in the development of efficient stroke nanotherapeutics. Herein, we have developed an effective stroke treatment agent based on monodisperse ceria nanoparticles, which are loaded with edaravone and modified with Angiopep-2 and poly(ethylene glycol) on their surface (E-A/P-CeO2). The as-designed E-A/P-CeO2 features highly effective BBB crossing via receptor-mediated transcytosis to access brain tissues and synergistic elimination of ROS by both the loaded edaravone and ceria nanoparticles. As a result, the E-A/P-CeO2 with low toxicity and excellent hemo/histocompatibility can be used to effectively treat strokes due to great intracephalic uptake enhancement and, in the meantime, effectively protect the BBB, holding great potentials in stroke therapy with much mitigated harmful side effects and sequelae
学科主题	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000440505000044
资助机构	This work was financially supported by National Natural Science Foundation of China (Grant Nos. 51502326 and 51702349), Shanghai Yangfan Program (16YF1412800), Youth Innovation Promotion Association Chinese Academy of Sciences (Grant No. 2017299), Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201704). ; This work was financially supported by National Natural Science Foundation of China (Grant Nos. 51502326 and 51702349), Shanghai Yangfan Program (16YF1412800), Youth Innovation Promotion Association Chinese Academy of Sciences (Grant No. 2017299), Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201704).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24832]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Bao, Qunqun,Hu, Ping,Xu, Yingying,et al. Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles[J]. ACS NANO,2018,12(7):6794, 6805.
APA	Bao, Qunqun.,Hu, Ping.,Xu, Yingying.,Cheng, Tiansheng.,Wei, Chenyang.,...&Shi, Jianlin.(2018).Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles.ACS NANO,12(7),6794.
MLA	Bao, Qunqun,et al."Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles".ACS NANO 12.7(2018):6794.