Mitochondria-Targeted Artificial "Nano-RBCs" for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation

doi:10.1002/advs.201800049

	Mitochondria-Targeted Artificial "Nano-RBCs" for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation
	Zhang, Liang ; Wang, Dong ; Yang, Ke 1; Sheng, Danli 2; Tan, Bin 1; Wang, Zhigang 2; Ran, Haitao 2; Yi, Hengjing 2; Zhong, Yixin 2; Lin, Han 3
刊名	ADVANCED SCIENCE
	2018
卷号	5 期号:8
关键词	nanoliposomes nanomedicine perfluorooctyl bromide photodynamic therapy photothermal therapy
ISSN号	2198-3844
DOI	10.1002/advs.201800049
英文摘要	Phototherapy has emerged as a novel therapeutic modality for cancer treatment, but its low therapeutic efficacy severely hinders further extensive clinical translation and application. This study reports amplifying the phototherapeutic efficacy by constructing a near-infrared (NIR)-responsive multifunctional nanoplatform for synergistic cancer phototherapy by a single NIR irradiation, which can concurrently achieve mitochondria-targeting phototherapy, synergistic photothermal therapy (PTT)/photodynamic therapy (PDT), self-sufficient oxygen-augmented PDT, and multiple-imaging guidance/monitoring. Perfluorooctyl bromide based nanoliposomes are constructed for oxygen delivery into tumors, performing the functions of red blood cells (RBCs) for oxygen delivery (Nano-RBC nanosystem), which can alleviate the tumor hypoxia and enhance the PDT efficacy. The mitochondria-targeting performance for enhanced and synergistic PDT/PTT is demonstrated as assisted by nanoliposomes. In particular, these Nano-RBCs can also act as the contrast agents for concurrent computed tomography, photoacoustic, and fluorescence multiple imaging, providing the potential imaging capability for phototherapeutic guidance and monitoring. This provides a novel strategy to achieve high therapeutic efficacy of phototherapy by the rational design of multifunctional nanoplatforms with the unique performances of mitochondria targeting, synergistic PDT/PTT by a single NIR irradiation (808 nm), self-sufficient oxygen-augmented PDT, and multiple-imaging guidance/monitoring.
学科主题	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
出版者	WILEY
WOS记录号	WOS:000441869400009
资助机构	The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant Nos. 81571688, 81771845, 51722211, 51672303, 31630026, and 81630047), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). ; The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant Nos. 81571688, 81771845, 51722211, 51672303, 31630026, and 81630047), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24758]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, Chongqing 400010, Peoples R China 2.Chongqing Med Univ, Childrens Hosp, Pediat Res Inst, Chongqing 400014, Peoples R China 3.Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Liang,Wang, Dong,Yang, Ke,et al. Mitochondria-Targeted Artificial "Nano-RBCs" for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation[J]. ADVANCED SCIENCE,2018,5(8).
APA	Zhang, Liang.,Wang, Dong.,Yang, Ke.,Sheng, Danli.,Tan, Bin.,...&Chen, Yu.(2018).Mitochondria-Targeted Artificial "Nano-RBCs" for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation.ADVANCED SCIENCE,5(8).
MLA	Zhang, Liang,et al."Mitochondria-Targeted Artificial "Nano-RBCs" for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation".ADVANCED SCIENCE 5.8(2018).