Magnesium-Engineered Silica Framework for pH-Accelerated Biodegradation and DNAzyme-Triggered Chemotherapy

doi:10.1002/smll.201800708

	Magnesium-Engineered Silica Framework for pH-Accelerated Biodegradation and DNAzyme-Triggered Chemotherapy
	Yu, Luodan 1; Chen, Yu ; Lin, Han 1; Gao, Shanshan 1; Chen, Hangrong ; Shi, Jianlin
刊名	SMALL
	2018
卷号	14 期号:35
关键词	biodegradability cancer therapy controllable drug release DNAzyme mesoporous silica
ISSN号	1613-6810
DOI	10.1002/smll.201800708
英文摘要	Inorganic nanocarriers have shown their high performance in disease theranostics in preclinical animal models and further great prospects for clinical translation. However, their dissatisfactory biodegradability and pre-drug leakage with nonspecificity to lesion sites significantly hinders the possible clinical translation. To solve these two critical issues, a framework-engineering strategy is introduced to simultaneously achieve enhanced biodegradability and controllable drug releasing, based on the mostly explored mesoporous silica-based nanosystems. The framework of mesoporous silica is engineered by direct Mg doping via a generic dissolution and regrowth approach, and it can transform into the easy biodegradation of magnesium silicate nanocarriers with simultaneous on-demand drug release. Such magnesium silicate nanocarriers can respond to the mild acidic environment of tumor tissue, causing the fast breaking up and biodegradation of the silica framework. More interesting, the released Mg2+ can further activate Mg2+-dependent DNAzyme on the surface of hollow mesoporous magnesium silicate nanoparticles (HMMSNs) to cleave the RNA-based gatekeeper, which further accelerates the release of loaded anticancer drugs. Therefore, enhanced anticancer efficiency of chemotherapeutic drugs assisted by the biodegradable intelligent HMMSNs is achieved. The high biocompatibility of nanocarriers and biodegradation products is demonstrated and can be easily excreted via feces and urine guaranteeing their further clinical translation.
学科主题	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000443012700001
资助机构	The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700, 2017YFB0702602), National Natural Science Foundation of China (Grant No. 51772316, 51672303, 51722211, and 81720108023), the National Natural Science Foundation of China (Grant No. 51772316), the National Key Research and Development Program of China (Grant No. 2017YFB0702602), and the Key Project of International Cooperation and Exchange of NSFC (No. 81720108023). Ethics statement: All the animal experiments were performed under the protocols approved by the Department of Laboratory Animal Science, Fudan University. All animal experiments were in agreement with the guidelines of the Institutional Animal Care and Use Committee (IACUC) of Department of Laboratory Animal Science, Fudan University. ; The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700, 2017YFB0702602), National Natural Science Foundation of China (Grant No. 51772316, 51672303, 51722211, and 81720108023), the National Natural Science Foundation of China (Grant No. 51772316), the National Key Research and Development Program of China (Grant No. 2017YFB0702602), and the Key Project of International Cooperation and Exchange of NSFC (No. 81720108023). Ethics statement: All the animal experiments were performed under the protocols approved by the Department of Laboratory Animal Science, Fudan University. All animal experiments were in agreement with the guidelines of the Institutional Animal Care and Use Committee (IACUC) of Department of Laboratory Animal Science, Fudan University.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24713]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yu, Luodan,Chen, Yu,Lin, Han,et al. Magnesium-Engineered Silica Framework for pH-Accelerated Biodegradation and DNAzyme-Triggered Chemotherapy[J]. SMALL,2018,14(35).
APA	Yu, Luodan,Chen, Yu,Lin, Han,Gao, Shanshan,Chen, Hangrong,&Shi, Jianlin.(2018).Magnesium-Engineered Silica Framework for pH-Accelerated Biodegradation and DNAzyme-Triggered Chemotherapy.SMALL,14(35).
MLA	Yu, Luodan,et al."Magnesium-Engineered Silica Framework for pH-Accelerated Biodegradation and DNAzyme-Triggered Chemotherapy".SMALL 14.35(2018).