Synergistic Effects of N/Cu Dual Ions Implantation on Stimulating Antibacterial Ability and Angiogenic Activity of Titanium

doi:10.1021/acsbiomaterials.8b00501

	Synergistic Effects of N/Cu Dual Ions Implantation on Stimulating Antibacterial Ability and Angiogenic Activity of Titanium
	Xia, Chao 1; Cai, Dingsen ; Tan, Ji 1; Li, Kunqiang 1; Qiao, Yuqin ; Liu, Xuanyong
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2018
卷号	4 期号:9 页码:3185
关键词	titanium nitride copper ion implantation galvanic corrosion antibacterial ability angiogenic activity
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.8b00501
英文摘要	Titanium and its alloys have been commonly used as implant materials. However, the inherent bioinert nature hinders its good osseointegration which limits its permanent clinical applications. In this work, nitrogen (N) and copper (Cu) dual ions were implanted into titanium by plasma immersion ion implantation and deposition (PIII&D) technology. The corrosion resistance, mechanical property, antibacterial ability, and angiogenic activity of the modified titanium surfaces were investigated. Experimental results show that titanium nitride (TiN) film embedded with Cu nanoparticles (Cu NPs) forms on the surface of the N/Cu dual ions implanted titanium. The N/Cu dual ions implanted titanium exhibits excellent corrosion resistance and mechanical property. The galvanic corrosion of Cu/TiN can effectively control copper ion release to enhance the antibacterial and angiogenic performances of the Ti surface.
学科主题	Materials Science, bioMaterials
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000444526900008
资助机构	Financial support from the National Key Research and Development Program of China (2016YFC1100604), the National Natural Science Foundation for Distinguished Young Scholars of China (51525207), National Natural Science Foundation of China (31570973), Shanghai Committee of Science and Technology, China (17441904000, 15441904900), International Partnership Program of Chinese Academy of Sciences Grant GJHZ1850 are acknowledged. ; Financial support from the National Key Research and Development Program of China (2016YFC1100604), the National Natural Science Foundation for Distinguished Young Scholars of China (51525207), National Natural Science Foundation of China (31570973), Shanghai Committee of Science and Technology, China (17441904000, 15441904900), International Partnership Program of Chinese Academy of Sciences Grant GJHZ1850 are acknowledged.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24687]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xia, Chao,Cai, Dingsen,Tan, Ji,et al. Synergistic Effects of N/Cu Dual Ions Implantation on Stimulating Antibacterial Ability and Angiogenic Activity of Titanium[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(9):3185, 3193.
APA	Xia, Chao,Cai, Dingsen,Tan, Ji,Li, Kunqiang,Qiao, Yuqin,&Liu, Xuanyong.(2018).Synergistic Effects of N/Cu Dual Ions Implantation on Stimulating Antibacterial Ability and Angiogenic Activity of Titanium.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(9),3185.
MLA	Xia, Chao,et al."Synergistic Effects of N/Cu Dual Ions Implantation on Stimulating Antibacterial Ability and Angiogenic Activity of Titanium".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.9(2018):3185.